63401-12-7

Basic information

• Product Name: 1-(2-piperidyl)propan-1-ol
• CAS NO: 63401-12-7
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• Mol File: 63401-12-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(2-piperidyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-piperidyl)propan-1-ol(63401-12-7)
• EPA Substance Registry System: 1-(2-piperidyl)propan-1-ol(63401-12-7)

Safety Data

• Hazardous Substances Data: 63401-12-7(Hazardous Substances Data)

Usage

General Description

1-(2-piperidyl)propan-1-ol is a chemical compound with the molecular formula C8H17NO. It is a primary alcohol with a piperidine ring attached to a propane chain. 1-(2-piperidyl)propan-1-ol is used in organic synthesis and as a building block in the manufacturing of pharmaceuticals and agrochemicals. It may also have potential applications in the development of new drugs due to its unique structure and properties. Additionally, it is important to handle this chemical with caution and follow proper safety protocols due to its potential hazards as a flammable liquid and irritant to the skin and eyes.

Upstream product

• 38726-77-1 conhydrinone hydrochloride 
• 1210445-07-0 (R)-6-((S)-1-(tert-butyldimethylsilyloxy)propyl)piperidin-2-one 
• 1403599-33-6 benzyl (3R,4S)-4-(benzyloxy)-1-phenylhex-1-en-3-ylcarbamate 
• 1403599-36-9 (R)-6-[(S)-1-(benzyloxy)propyl]-1,2,3,6-tetrahydropyridine 
• 1403599-35-8 (3R,4S)-4-(benzyloxy)-N-(but-3-enyl)-1-phenylhex-1-en-3-amine 
• 1403599-34-7 (3R,4S,Z)-4-(benzyloxy)-1-phenylhex-1-en-3-amine 
• 444564-15-2 (1R,2S,2S)-(-)-N-[2-(tert-butyldimethylsilyloxy)-1-(3-[1,3]dioxolan-2-yl-propyl)-butyl]-N-(2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 262844-06-4 (2R,3S)-2,3-dihydroxypentanoic acid methyl ester 
• 869660-17-3 (5R,6S)-5-azido-6-benzyloxyoct-3-en-1-ol 
• 869660-16-2 (2R,3S)-2-azido-3-benzyloxypentan-1-ol 
• 1027159-97-2 (2S,3S)-2-Azido-3-benzyloxy-pentanal 
• 869660-15-1 (2R,3S)-2-azido-1,3-O-benzylidenepentane-1,3-diol 
• 869747-48-8 (2S,3S)-1,3-O-benzylidenepentane-1,2,3-triol 
• 6026-86-4 methyl 4-formylbutanoate 

Downstream Products

• 97073-23-9 1-(2-piperidyl)-1-propanone 
• 80933-75-1 1-(3,4,5,6-tetrahydro-2-pyridyl)-1-propanone 

Relevant articles and documents

Stereoselective synthesis of (-)-α-conhydrine and its pyrrolidine analogue

The stereoselective synthesis of (-)-α-conhydrine and its pyrrolidine analogue was achieved from readily available D-erythronolactone. The key step of this synthesis includes a highly regioselective and diastereoselective addition of chlorosulfonyl isocyanate to 1,2-anti-dibenzyl ether to afford the 1,2-anti-amino alcohol. The total synthesis of (-)-α-conhydrine and its pyrrolidine analogue starting from readily available D-erythronolactone was achieved via the regioselective and diastereoselective allylic amination of anti-1,2-dibenzyl ether by using chlorosulfonyl isocyanate.

Highly enantioselective synthesis of chiral cyclic amino alcohols and conhydrine by ruthenium-catalyzed asymmetric hydrogenation

A highly efficient enantio- and diastereoselective synthesis of chiral cis-β-N-alkyl/arylamino cyclic alcohols has been realized by asymmetric hydrogenation of racemic α-amino cyclic ketones via DKR catalyzed by [RuCl2((S)-Xyl-SDP)((R,R)-DPEN)]. The enantioselectivities of the reaction were up to 99.9% ee with 99:1 cis-selectivities. A practical catalytic asymmetric synthesis of all four isomers of conhydrine was also developed.

Asymmetric synthesis of (-)-α-conhydrine

The enantioselective synthesis of (-)-α-conhydrine has been achieved by two different synthetic routes. The key steps include Sharpless asymmetric dihydroxylation, regioselective opening of a cyclic sulfate and Wittig olefination.