63402-63-1Relevant academic research and scientific papers
LTA4 Hydrolase inhibitors
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Page 101, (2010/01/31)
The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as proriasis, ulcerative colitis, IBD and asthma.
Design, synthesis, and anti-Trypanosoma cruzi evaluation of a new class of cell-growth inhibitors structurally related to Fenoxycarb
Schvartzapel,Fichera,Esteva,Rodriguez,Gros
, p. 1207 - 1214 (2007/10/02)
Several compounds, structurally related to the insect-growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood-bank sterilization or Chagas'-disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity.
