25345-76-0

Usage

Physical state

Colorless liquid

Molecular weight

226.27 g/mol

Structural features

+ Phenoxy group attached to the 1 position
+ Prop-2-en-1-yloxy group attached to the 4 position

Industrial and laboratory applications

+ Chemical intermediate
+ Reagent in organic synthesis
+ Production of polymers and plastics

Potential uses

+ Pharmaceuticals
+ Pesticides

Upstream product

• 831-82-3 4-Phenoxyphenol 
• 1730-25-2 allylmagnesium bromide 
• 106-95-6 allyl bromide 
• 107-05-1 3-chloroprop-1-ene 
• 108-95-2 phenol 
• 67-36-7 4-phenoxy benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 63402-63-1 3-(4-phenoxyphenoxy)-propan-1-ol 
• 84267-54-9 2-[(4-phenoxyphenoxy)methyl]oxirane 
• 445283-08-9 4-phenoxy(prop-2-en-1-yl)phenoxyethyl 4-toluenesulfonate 
• 445283-03-4 2-(E-[prop-1-en-1-yl])-4-phenoxyphenoxyethyl 4-toluenesulfonate 
• 445283-01-2 2-{2-[4-Phenoxy-2-((E)-propenyl)-phenoxy]-ethoxy}-tetrahydro-pyran 
• 445283-06-7 2-[2-(2-allyl-4-phenoxy-phenoxy)-ethoxy]-tetrahydro-pyran 
• 445283-07-8 4-phenoxy(prop-2-en-1-yl)phenoxyethanol 
• 445283-02-3 2-(E-[prop-1-en-1-yl])-4-phenoxyphenoxyethanol 
• 606966-62-5 hydroxy-{3-[4-(4-phenoxy-2-propyl-phenoxy)-butoxy]-phenyl}-acetic acid methyl ester 
• 228578-00-5 methyl 3-(3-(2-propyl-4-phenoxyphenoxy)propoxy)-mandelate 
• 823221-77-8 1-methoxymethoxy-3-(4-phenoxy-phenoxy)propan-2-ol 

Relevant academic research and scientific papers

Metal-free Photochemical Atom Transfer Radical Addition (ATRA) of BrCCl3 to Alkenes

A simple, photochemical, and metal-free protocol for the atom transfer radical addition (ATRA) of bromotrichloromethane onto various alkenes is described. Among a range of organic molecules, phenylglyoxylic acid proved to be the most suitable photoinitiator to promote a sustainable process for the addition of bromotrichloromethane to olefins. This photochemical atom transfer radical protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields.

Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation-Cyclization of Allylphenols

A green and cheap protocol for the synthesis of dihydrobenzofurans via an organocatalytic oxidation of o -allylphenols is presented. The use of 2,2,2-trifluoroacetophenone and H 2 O 2 as the oxidation system, leads to a highly useful synthetic method, where a variety of substituted o -allylphenols were cyclized in high yields..

Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation

The obligate intracellular parasite, Trypanosoma cruzi is the etiologic agent of Chagas disease or American trypanosomiasis, which is the most prevalent parasitic disease in the Americas. The present chemotherapy to control this illness is still deficient

5-Aryl thiazolidine-2,4-diones: Discovery of PPAR dual α/γ agonists as antidiabetic agents

A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARα/γ agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia.

LTA4 Hydrolase inhibitors

The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as proriasis, ulcerative colitis, IBD and asthma.

Antidiabetic agents

The instant invention is concerned with aryl and heteroaryl oxyacetic acid type compounds which are useful antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and related diseases and for lowering triglyceride levels are also disclosed.

Design, synthesis, and anti-Trypanosoma cruzi evaluation of a new class of cell-growth inhibitors structurally related to Fenoxycarb

Several compounds, structurally related to the insect-growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T. cruzi making them promising good candidates either for blood-bank sterilization or Chagas'-disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity.

Arylacetic acid derivatives

Arylacetic acid derivatives of the formula STR1 with R1, R2 and R3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are practiced by catalytic hydrogenation of new compounds of the formula STR2 in which R and R10 are also specifically defined. The method of making the latter compound is also set forth.