25345-76-0

Basic information

• Product Name: 1-phenoxy-4-(prop-2-en-1-yloxy)benzene
• Synonyms: Benzene, 1-phenoxy-4-(2-propen-1-yloxy)-
• CAS NO: 25345-76-0
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.2705
• Mol File: 25345-76-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 333.4°C at 760 mmHg
• Flash Point: 130.5°C
• Density: 1.066g/cm³
• Vapor Pressure: 0.000265mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 1-phenoxy-4-(prop-2-en-1-yloxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenoxy-4-(prop-2-en-1-yloxy)benzene(25345-76-0)
• EPA Substance Registry System: 1-phenoxy-4-(prop-2-en-1-yloxy)benzene(25345-76-0)

Safety Data

• Hazardous Substances Data: 25345-76-0(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Molecular weight

226.27 g/mol

Structural features

+ Phenoxy group attached to the 1 position
+ Prop-2-en-1-yloxy group attached to the 4 position

Industrial and laboratory applications

+ Chemical intermediate
+ Reagent in organic synthesis
+ Production of polymers and plastics

Potential uses

+ Pharmaceuticals
+ Pesticides

Upstream product

• 831-82-3 4-Phenoxyphenol 
• 106-95-6 allyl bromide 
• 107-05-1 3-chloroprop-1-ene 
• 1730-25-2 allylmagnesium bromide 
• 108-95-2 phenol 
• 459-57-4 4-fluorobenzaldehyde 
• 67-36-7 4-phenoxy benzaldehyde 

Downstream Products

• 228578-00-5 methyl 3-(3-(2-propyl-4-phenoxyphenoxy)propoxy)-mandelate 
• 606966-62-5 hydroxy-{3-[4-(4-phenoxy-2-propyl-phenoxy)-butoxy]-phenyl}-acetic acid methyl ester 
• 445283-08-9 4-phenoxy(prop-2-en-1-yl)phenoxyethyl 4-toluenesulfonate 
• 445283-03-4 2-(E-[prop-1-en-1-yl])-4-phenoxyphenoxyethyl 4-toluenesulfonate 
• 445283-01-2 2-{2-[4-Phenoxy-2-((E)-propenyl)-phenoxy]-ethoxy}-tetrahydro-pyran 
• 445283-06-7 2-[2-(2-allyl-4-phenoxy-phenoxy)-ethoxy]-tetrahydro-pyran 
• 445283-07-8 4-phenoxy(prop-2-en-1-yl)phenoxyethanol 
• 445283-02-3 2-(E-[prop-1-en-1-yl])-4-phenoxyphenoxyethanol 
• 823221-77-8 1-methoxymethoxy-3-(4-phenoxy-phenoxy)propan-2-ol 
• 194792-58-0 2-propyl-4-phenoxyphenol 

Relevant articles and documents

Metal-free Photochemical Atom Transfer Radical Addition (ATRA) of BrCCl3 to Alkenes

A simple, photochemical, and metal-free protocol for the atom transfer radical addition (ATRA) of bromotrichloromethane onto various alkenes is described. Among a range of organic molecules, phenylglyoxylic acid proved to be the most suitable photoinitiator to promote a sustainable process for the addition of bromotrichloromethane to olefins. This photochemical atom transfer radical protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields.

Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation-Cyclization of Allylphenols

A green and cheap protocol for the synthesis of dihydrobenzofurans via an organocatalytic oxidation of o -allylphenols is presented. The use of 2,2,2-trifluoroacetophenone and H 2 O 2 as the oxidation system, leads to a highly useful synthetic method, where a variety of substituted o -allylphenols were cyclized in high yields..

LTA4 Hydrolase inhibitors

The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as proriasis, ulcerative colitis, IBD and asthma.