6341-99-7

Basic information

• Product Name: 4-chloro-2-methylphenyl acetate
• Synonyms: 4-Chloro-2-methylphenyl acetate; phenol, 4-chloro-2-methyl-, acetate
• CAS NO: 6341-99-7
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.6196
• Mol File: 6341-99-7.mol

Chemical Properties

• Boiling Point: 247.6°C at 760 mmHg
• Flash Point: 114.1°C
• Density: 1.188g/cm³
• Vapor Pressure: 0.0255mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: 4-chloro-2-methylphenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-methylphenyl acetate(6341-99-7)
• EPA Substance Registry System: 4-chloro-2-methylphenyl acetate(6341-99-7)

Safety Data

• Hazardous Substances Data: 6341-99-7(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
4-Chloro-2-methylphenyl acetate is used as a flavor and fragrance ingredient for its fruity, sweet odor. It is incorporated into various consumer products such as perfumes, cosmetics, and food to impart a pleasant aroma, enhancing the sensory experience of these products.
Used in Pharmaceutical Synthesis:
4-chloro-2-methylphenyl acetate is utilized in the synthesis of pharmaceuticals and other organic compounds due to its unique chemical properties. Its reactivity and structural features make it a valuable intermediate in the development of new drugs and medicinal agents.
Used in Personal Care and Household Products:
4-Chloro-2-methylphenyl acetate is used as an aromatic component in personal care and household products to provide a pleasant scent. Its addition to these products can improve consumer appeal and create a more enjoyable user experience.
Safety Precautions:
Due to its potential hazards and risks associated with its use, 4-chloro-2-methylphenyl acetate should be handled and stored with proper safety measures. This includes following guidelines for chemical handling, using appropriate personal protective equipment, and ensuring proper ventilation during its use in various applications.

Upstream product

• 1570-64-5 2-methyl-4-chlorophenol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 1343513-60-9 C₁₆H₉BrCl₂O₂ 
• 1343513-58-5 C₁₆H₉BrClNO₄ 
• 344866-58-6 C₁₆H₁₂Cl₂O₃ 
• 1343513-56-3 C₁₆H₁₂Cl₂O₃ 
• 1343513-55-2 C₁₆H₁₂ClNO₅ 
• 1343513-50-7 6-chloro-2-(4-chlorophenyl)-8-(morpholinomethyl)-4H-chromen-4-one 
• 1343513-49-4 8-((1H-imidazol-1-yl)methyl)-6-chloro-2-(2-chlorophenyl)-4H-chromen-4-one 
• 1343513-48-3 6-chloro-2-(2-chlorophenyl)-8-((dimethylamino)methyl)-4H-chromen-4-one 
• 1343513-47-2 6-chloro-2-(2-chlorophenyl)-8-(piperazin-1-ylmethyl)-4H-chromen-4-one 
• 1343513-46-1 6-chloro-2-(2-chlorophenyl)-8-(morpholinomethyl)-4H-chromen-4-one 
• 1343513-45-0 6-chloro-2-(2-chlorophenyl)-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one 
• 1343513-44-9 6-chloro-2-(2-chlorophenyl)-8-(piperidin-1-ylmethyl)-4H-chromen-4-one 
• 1343513-43-8 6-chloro-2-(2-chlorophenyl)-8-((diethylamino)methyl)-4H-chromen-4-one 
• 1343513-42-7 8-((1H-imidazol-1-yl)methyl)-6-chloro-2-(4-nitrophenyl)-4H-chromen-4-one 

Relevant articles and documents

Iridium-Catalyzed C(sp3)?H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans

Intramolecular addition of an O-methyl C(sp3)?H bond across a carbon-carbon double bond occurs in the iridium-catalyzed reaction of methyl 2-(propen-2-yl)phenyl ethers. The Ir/(S)-DTBM-SEGPHOS catalyst promotes the reaction efficiently in toluene at 110–135 °C to afford 3,3-dimethyl-2,3-dihydrobenzofurans. Enantioselective C(sp3)?H addition is achieved in the reaction of methyl 2-(1-siloxyethenyl)phenyl ethers, affording enantioenriched 3-hydroxy-2,3-dihydrobenzofuran derivatives with up to 96% ee. (Figure presented.).

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Investigation on the substitution effects of the flavonoids as potent anticancer agents: A structure-activity relationships study

Three series of flavonoid analogues substituted with different aminomethyl substitutions at C-6, C-7, and C-8 were designed and synthesized for the structure-activity relationship studies as potent anticancer agents. The prepared analogues were evaluated for their in vitro inhibitory activity against the growth of the hepatic cancer cell lines HepG2 and SMMC-7721. Structure-activity relationships indicated that not only the compounds with amino methyl groups were more active than those without the groups in the same series but also the compounds substituted by aminomethyl groups at position C-8 were more active than those at positions C-6 and C-7.