63412-64-6Relevant academic research and scientific papers
Structure and conformations of monoacyl and diacyl 1,2,4-triazolidine-3,5-diones
Izydore, Robert A.,Ribeiro, Anthony A.,Hall, Iris H.
, p. 3733 - 3737 (1996)
A series of monoacyl and diacyl 1,2,4-triazolidine-3,5-diones substituted at position 4 with either a phenyl or a tert-butyl group was prepared. Both acetyl and benzoyl groups were utilized as the acyl substituents. The diacylated compounds containing one or two acetyl groups were somewhat unstable to moisture. The acylated compounds were studied by 1H, 13C and 15N NMR spectroscopy and X-ray crystallography to determine if they were acylated on nitrogen or ring carbonyl oxygen. The results indicated that the acylations occurred on nitrogen. The NMR spectra and molecular modeling computations were used to assign conformations to several of the diacylated compounds.
SAR and 3D-QSAR studies on thiadiazolidinone derivatives: Exploration of structural requirements for glycogen synthase kinase 3 inhibitors
Martinez, Ana,Alonso, Mercedes,Castro, Ana,Dorronsoro, Isabel,Gelpí, J. Luis,Luque, F. Javier,Pérez, Conceptión,Moreno, Francisco J.
, p. 7103 - 7112 (2007/10/03)
The 2,4-disubstituted thiadiazolidinones (TDZD) are described as the first ATP-noncompetitive GSK-3 inhibitors. Following an SAR study about TDZD, different structural modifications in the heterocyclic ring aimed to test the influence of each heteroatom o
