63416-65-9

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 123-54-6 acetylacetone 
• 345-35-7 2-fluorobenzyl chloride 

Downstream Products

• 63416-67-1 5-{2-[3-(2-Fluoro-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzoic acid methyl ester 
• 76727-26-9 4-(2-fluorophenyl)butan-2-ol 
• 64779-92-6 5-{2-[3-(2-Fluoro-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide 
• 148775-25-1 (E)-4-((2-fluorobenzene)yl)but-3-en-2-one 

Relevant academic research and scientific papers

Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists

Dopamine receptors play an integral role in controlling brain physiology. Importantly, subtype selective agonists and antagonists of dopamine receptors with biased signaling properties have been successful in treating psychiatric disorders with a low inci

Reactions of Co-ordinated Ligands. Part 10. Rhodium-catalysed Cyclisation of 3-(2-Fluorophenyl)propanols to Chromans

The cyclisation of several 3-(2-fluorophenyl)-propanols to the corresponding chroman occurs in nitromethane-acetone solution at 80 deg C when either the hexafluorophosphate (3) or tetrafluoroborate salt (4) of the (η5-ethyltetramethylcyclopentadienyl)(η6-benzene)rhodium(III) cation is used as a catalyst; the former salt is the more effective catalyst.The cyclisation is believed to involve the activation of the aryl fluoride (towards intramolecular nucleophilic substitution by the hydroxy group) by the formation of a metal complex in which the aryl fluoride is ?-bonded with the metal cation.It is suggested that the arene-exchange reaction which gives this ?-bonded complex proceeds faster with the salt (3) than with the salt (4), and that this is the main factor for the greater efficiency of the former salt as a cyclisation catalyst.

4-Hydroxy-1,3-benzenedimethanol derivatives

Compounds of the general formula (I): STR1 in which one or more substituents R1 may be present and in which: R1 represents a halogen atom, preferably fluorine or chlorine, or a trifluoromethyl group or a group --NR5 R6 in which R5 and R6 which may be the same or different represent a hydrogen atom, or an alkyl group containing from 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms or an acyl group, preferably the residue of a C1 -C6 alkanoic acid; X represents a straight or branched chain alkyl group containing 2 to 6 carbon atoms; and R2 and R3 which may be the same or different each represent a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, preferably a methyl group; and R4 represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, are provided together with processes for the production thereof. They have a β2 -stimulant activity.