148775-25-1

Basic information

• Product Name: 3-Buten-2-one, 4-(2-fluorophenyl)-, (3E)-
• CAS NO: 148775-25-1
• Molecular Formula: C10H9FO
• Molecular Weight: 164.179
• Mol File: 148775-25-1.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-one, 4-(2-fluorophenyl)-, (3E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4-(2-fluorophenyl)-, (3E)-(148775-25-1)
• EPA Substance Registry System: 3-Buten-2-one, 4-(2-fluorophenyl)-, (3E)-(148775-25-1)

Safety Data

• Hazardous Substances Data: 148775-25-1(Hazardous Substances Data)

Upstream product

• 445-27-2 2'-Fluoroacetophenone 
• 67-64-1 acetone 
• 446-52-6 2-Fluorobenzaldehyde 
• 75-36-5 acetyl chloride 
• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 63416-65-9 4-(2-fluorophenyl)butan-2-one 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 446-46-8 2-fluorobenzenediazonium tetrafluoroborate 
• 78-94-4 methyl vinyl ketone 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 102821-72-7 5-(2-fluorophenyl)-cyclohexane-1,3-dione 
• 1443780-52-6 4-(2-fluorophenyl)-4-phenylbutan-2-one 
• 1254200-34-4 (R)-dibenzyl 2-(1-(2-fluorophenyl)-3-oxobutyl)malonate 

Relevant articles and documents

Iron-Catalyzed ?±,?-Dehydrogenation of Carbonyl Compounds

An iron-catalyzed α,β-dehydrogenation of carbonyl compounds was developed. A broad spectrum of carbonyls or analogues, such as aldehyde, ketone, lactone, lactam, amine, and alcohol, could be converted to their α,β-unsaturated counterparts in a simple one-step reaction with high yields.

Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates

A stereodivergent Pd/Cu catalyst system has been developed for the unprecedented dynamic kinetic asymmetric transformation (DyKAT) of racemic unsymmetrical 1,3-disubstituted allylic acetates with prochiral aldimine esters. A series of α,α-disubstituted α-amino acids bearing vicinal stereocenters were easily prepared with excellent enantioselectivities (up to >99% ee) and diastereoselectivities (up to >20:1 dr). Moreover, all four stereoisomers of the product can be readily obtained simply by switching the configurations of the two chiral metal catalysts. Furthermore, the present work highlights the power of synergistic Pd/Cu catalysis consisting of two common bidentate chiral ligands for stereodivergent synthesis.

One-pot two-step chemoenzymatic deracemization of allylic alcohols using laccases and alcohol dehydrogenases

A series of enantioenriched (hetero)aromatic secondary allylic alcohols has been synthesized through deracemization of the corresponding racemic mixtures combining a non-selective chemoenzymatic oxidation (laccase from Trametes versicolor and oxy-radical TEMPO) and a stereoselective biocatalyzed reduction (lyophilized cells of E. coli overexpressing an alcohol dehydrogenase, ADH). Both steps were performed in aqueous medium under very mild reaction conditions. After optimization, a sequential one-pot two-step protocol was set up, obtaining the corresponding chiral alcohols in moderate to high conversions (48–95%) and enantiomeric excess (65->99% ee). Depending on the ADH stereopreference, both antipodes from these valuable chiral synthons could be prepared, even at preparative scale (119?178 mg), in a straightforward manner.