634192-41-9Relevant academic research and scientific papers
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB
Soellner, Matthew B.,Rawls, Katherine A.,Grundner, Christoph,Alber, Tom,Ellman, Jonathan A.
, p. 9613 - 9615 (2008/02/13)
A new substrate-based fragment approach for the identification of novel PTP inhibitors is presented. This method was applied to Mycobacterium tuberculosis PtpB, a promising new target for the treatment of tuberculosis. This resulted in the development of the most potent PtpB inhibitor reported to date (0.22 μM) with low molecular weight and good selectivity against a panel of other protein tyrosine phosphatases. Copyright
ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.
Edsall Jr., Richard J,Harris, Heather A,Manas, Eric S,Mewshaw, Richard E
, p. 3457 - 3474 (2007/10/03)
The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERbeta selectivity on the order of 20-70-fold.
