6342-48-9

Usage

Uses

Used in Environmental Monitoring and Regulation:
CAS 6342-48-9 is used as a reference chemical for monitoring and regulating environmental pollution levels. Its presence in the environment is a significant concern due to its extreme toxicity and long-lasting effects.
Used in Research and Toxicological Studies:
2,3,7,8-Tetrachlorodibenzo-p-dioxin is used as a subject in research and toxicological studies to better understand its harmful effects on human health and the environment. This helps in the development of strategies for controlling and eliminating this chemical.
Used in Risk Assessment and Management:
CAS 6342-48-9 is used in risk assessment and management processes to evaluate the potential hazards and risks associated with its presence in the environment. This aids in the implementation of appropriate measures to mitigate its impact on human health and the environment.
Used in Public Health and Safety Initiatives:
2,3,7,8-Tetrachlorodibenzo-p-dioxin is a key focus in public health and safety initiatives aimed at raising awareness about its harmful effects and promoting efforts to control and eliminate this chemical from the environment.

Upstream product

• 54-85-3 isoniazid 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 1372892-96-0 (E)-N'-{3-[(dimethylamino)methyl]-2-methoxybenzylidene}isonicotinoyl hydrazide 
• 1372893-03-2 C₂₅H₂₆ClN₅O₂ 
• 1372893-04-3 (19Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-chlorobenzenamine 
• 1372893-05-4 C₂₅H₂₆BrN₅O₂ 
• 1372893-06-5 C₂₅H₂₆BrN₅O₂ 
• 1372893-07-6 (19Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-bromobenzenamine 
• 1372893-08-7 C₂₅H₂₆N₆O₄ 
• 1372893-09-8 C₂₅H₂₆N₆O₄ 
• 1372893-10-1 (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-nitrobenzenamine 
• 1372893-11-2 C₂₆H₂₉N₅O₃ 
• 1372893-12-3 C₂₆H₂₉N₅O₃ 
• 1372893-13-4 (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-methoxybenzenamine 
• 1372892-97-1 1-(2-(3-((dimethylamino)methyl)-2-methoxyphenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanone 
• 1372892-98-2 (19Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)benzenamine 

Relevant academic research and scientific papers

Investigation of nicotinamide and isonicotinamide derivatives: A quantitative and qualitative structural analysis

An anhydrous nature of benzylidene derivatives of nicotin and isonicotinamides crystal structures is determined and studied for their weak intermolecular interactions. The molecular structure is non-planar in general with the pyridine ring twisted with re

Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells

Higher levels of copper, reduced glutathione (GSH) and reactive oxygen species (ROS) observed in cancer cells than in normal cells, favor the idea of developing copper ionophores as prooxidative anticancer agents (PAAs) to hit the altered redox homeostasi

Eco-friendly and highly efficient synthesis, including multigram synthesis, of aldehyde isonicotinoyl hydrazones using sonochemistry

Background: The isoniazid has been a key compound in first-line tuberculosis (TB) treatment, usually in combination with other drugs. Following on from the use of isoniazid itself, various derivatives of isoniazid have also been investigated as anti-TB ag

An efficient alkynylation of 4-thiazolidinone with terminal alkyne under C-H functionalisation

A method of palladium catalysed efficient alkynylation through the cross coupling reaction of terminal alkynes with the slightly more acidic C-H bonds of 4-thiazolidinone has been developed. This method allows the direct introduction of an ethynyl group into the 4-thiazolidinone moiety. Mild reaction conditions involving aerial oxidation and one pot synthesis make this reaction more efficient for the formation of sp3(C)-sp(C) bond.

New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation

Structural modifications of the front line antitubercular drug isoniazid provide lipophilic adaptations of the drug in which the hydrazide moiety of isoniazid is replaced by 1,3,4-oxadiazole heterocycles to eliminate in vivo acetylation by arylamine N-ace

Synthesis and characterization of (Z)-N-(1-[2-{3-[(dimethylamino)methyl)]- 2-methoxyphenyl}-5-(pyridin-4-YL)-1,3,4-oxadiazol-3(2H)-YL]ethylidene) benzenamine derivatives as potent antifungal agents

In the present study, a series of (Z)-N-(1-[2-{3-[(dimethylamino)methyl)]- 2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene) benzenamine derivatives have been synthesized and characterized by IR, 1H NMR and 13C NMR spectra. All the sy

Synthesis, characterization of (E)-N'-(substituted-benzylidene) isonicotinohydrazide derivatives as potent antitubercular agents

A series of 19 isonicotinic acid hydrazide derivatives has been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using alamar blue susceptibility test. The synthesized comp

Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives

A series of 22 (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and