634203-87-5

Upstream product

• 146803-45-4 N-(fluorenylmethyloxycarbonyl)-L-aspart-α-al β-tert-butyl ester 
• 204973-60-4 N-(9-fluorenylmethoxycarbonyl)-N’-methoxy-N’-methyl-L-isoasparagine t-butyl ester 
• 71989-14-5 Fmoc-(tBu)Asp-OH 

Relevant academic research and scientific papers

Acyl dipeptides as reversible caspase inhibitors. Part 1: Initial lead optimization

Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8.

(Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases

This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of pa