63422-23-1

Upstream product

• 100969-62-8 N-(3-hydroxy-4-methoxy-benzyliden)-anthranilic acid amide 
• 621-59-0 isovanillin 
• 55-21-0 benzamide 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 1272644-81-1 2-(3-(4-bromobutoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 1272644-89-9 2-(4-methoxy-3-(4-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)phenoxy)butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 1272644-91-3 2-(3-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 101575-17-1 2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one 

Relevant academic research and scientific papers

Mercuric chloride catalyzed synthesis of some anticancer 2-aryl-2,3-dihydroquinizolin-4(1H)-ones

A series of ten 2,3-dihydroquinizolin-4(1H)-one derivatives were synthesized by ethanol-mediated condensation of anthranilamide with various aryl aldehydes in presence of catalytic amount of mercuric chloride (HgCl2). The temperature of the reactions was maintained at 60 °C for good yield of the products. The highlights of the method include use of lab grade of chemicals as reagents and ease of work up in obtaining the product with high purity. Out of ten derivatives synthesized, three compounds 3f, 3i, and 3j are new and all the compounds were evaluated for their cytotoxic activity against six cancer cell lines. The compounds 3b (IC50: 26.1 μg mL?1), 3c (42.7 μg mL?1) ,and 3e (31.1 μg mL?1) have shown activity against the cell line MDA-MB-231. Compounds 3b, 3c, 3d, 3e, and 3g showed significant total growth inhibition (TGI) values against the cell line MDA-MB-231 and compound 3j showed good TGI value against the cell line PANC 1. Compounds were also screened for their antibacterial activity and antioxidant activity by DPPH method.

PEG-SO3H as eco-friendly polymeric catalyst for the synthesis of 2,3-dihydroquinazolinones in water

A facile, efficient, green, and environmentally benign method is described for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones by direct cyclocondensation of 2-aminobenzamide with aldehydes or ketones in water using PEG-SO3H as an acidic catalyst under room temperature. This new method totally avoids the use of organic acids, toxic or expensive solvents and affording the corresponding product in good to excellent yields in this reaction.

Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents

A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate.