101575-17-1

Basic information

• Product Name: 2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one
• Synonyms: 2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one
• CAS NO: 101575-17-1
• Molecular Weight: 298.342
• Mol File: 101575-17-1.mol

Chemical Properties

• CAS DataBase Reference: 2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one(101575-17-1)
• EPA Substance Registry System: 2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one(101575-17-1)

Safety Data

• Hazardous Substances Data: 101575-17-1(Hazardous Substances Data)

Upstream product

• 64-67-5 diethyl sulfate 
• 63422-23-1 2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 100969-62-8 N-(3-hydroxy-4-methoxy-benzyliden)-anthranilic acid amide 
• 1131-52-8 3-ethoxy-4-methoxybenzaldehyde 
• 28144-70-9 anthranilic acid amide 

Relevant articles and documents

Synthesis, anticancer and antioxidant evaluation of some new 2-aryl and 2-pyrazole-2,3-dihydroquinazolin-4(1H)-ones

A new and direct synthetic method was developed for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones by condensing 2-aminobenzamide and aldehydes in ethanol using thionyl chloride as a catalyst at room temperature. The simple reaction conditions, small timing, easy work up and very good yields are the greatest advantages of this methodology. By utilizing the approach six novel derivatives of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones (3a-3f) were synthesized. All the compounds were tested for their anticancer activity on A549 cell line and antioxidant activity by using DPPH method. Compounds 3c (74.22 %) and 3e (73.45 %) showed better anticancer activity towards the A549 cell line.