63429-76-5Relevant academic research and scientific papers
TBHP/NH4I-Mediated Direct N-H Phosphorylation of Imines and Imidates
Wang, Xiaofeng,Ou, Yingcong,Peng, Zhenbo,Yu, Guodian,Huang, Yuanting,Li, Xianwei,Huo, Yanping,Chen, Qian
, p. 14949 - 14956 (2019/11/11)
A direct and practical metal-free N-H phosphorylation has been achieved via the TBHP/NH4I-mediated cross-dehydrogenative coupling (CDC) reactions between imines/imidates and P(O)H compounds. This transformation provides an efficient synthetic r
Tertiary α-diarylmethylamines derived from diarylketimines and organomagnesium reagents
Desmarchelier, Alaric,Ortiz, Pablo,Harutyunyan, Syuzanna R.
, p. 703 - 706 (2015/01/09)
Organomagnesium reagents enable swift and versatile derivatisation of diarylimines to the corresponding α-substituted diarylmethylamines in excellent yields, through fast and clean reactions. Where it occurs, 1,2-reduction can be circumvented using readily accessible dialkylmagnesium reagents. This journal is
Synthesis and characterization of new ca-disubstituted (diarylaminomethyl)phosphonates
Cristau, Henri-Jean,Lambert, Jean-Marc,Pirat, Jean-Luc
, p. 1167 - 1170 (2007/10/03)
A convenient and efficient three-step procedure for the preparation of W-protected or unprotected C-disubstituted (di-arylaminomethyOphosphonates 1 is reported. This method allows diversification of the substituents on the carbon in the a-position to the phosphorus, as well as the protective group on the amine and the phosphonate ester group.
The Reaction Between Oximes and Tervalent Phosphorus Compounds: A Low-Temperature Radical Rearrangement Process
Hudson, Robert F.,Brown, Charles,Maron, A.
, p. 2560 - 2573 (2007/10/02)
Ketoximes react rapidly with X2PCl compounds where X = Ph, Me2N, EtO and X2 = OCH2CH2O at low temperatures (-60 to -80 deg C) in the presence of triethylamine to give a PIII intermediate 2, which rearranges by a unimolecular process to the corresponding N-phosphinylated imine 3.Free radicals, formed by capture of the initially produced phosphonyl radical, are detected by ESR spectroscopy, and evidence for a radical cage process is obtained from 31P CIDNP studies.Where X2 = OCH2CH2O, the PIII intermediate (2d, e) can be isolated, and the structure established from 13C NMR spectra.Kinetic measurements show compound 2e to rearrange (30 - 60 deg C) ca. 10 times more slowly than the open chain compound (X = OEt), and the negative activation entropy suggests that this particular system (2e) rearranges, in part, by a cyclic transition state.
