63435-69-8Relevant academic research and scientific papers
Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin
Moustafa,El-Emam,Subbagh,Sharaf El-Din
, p. 1076 - 1078 (2007/10/02)
The in-vivo metabolic conversion of equal mixture of phenytoin and decadeuteriophenytoin to the para-hydroxy metabolite in rat was investigated in order to verify a possible role of an insertion or abstraction mechanisms in the hydroxylation process. Determination of k(H)/k2(H) values of urine samples at 2 h intervals for 24 h indicated that there was no isotope effect during in-vivo para-hydroxylation of phenytoin. This gives evidence of the arene oxide intermediacy possibly being the sole pathway for para-hydroxylation of phenytoin.
Use of stable isotopes in the study of pharmacokinetics of drugs by mass fragmentography II. Detailed examination of pharmacokinetics of a single oral dose of phenytoin in humans
Baba,Goromaru,Yamazaki,Kasuya
, p. 1300 - 1307 (2007/10/02)
To study the pharmacokinetics of phenytoin in detail, a mass fragmentographic method was applied for the precise, sensitive, and specific analysis of phenytoin, 5-(4-hydroxyphenyl)-5-phenylhydantoin, and 5-(4-hydroxyphenyl)-5-phenylhydantoin glucuronide i
