6345-63-7

Basic information

• Product Name: 2-nitrobenzylidene di(acetate)
• Synonyms: 2-nitrobenzylidene di(acetate);2-Nitrobenzaldiacetate;(2-Nitrophenyl)diacetoxymethane;(2-Nitrophenyl)methanediol diacetate;2-Nitro-1-(diacetoxymethyl)benzene;2-Nitrophenylmethanediol diacetate;Diacetic acid o-nitrobenzylidene ester;o-Nitrobenzal Diacetate 98%
• CAS NO: 6345-63-7
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.20814
• EINECS: 228-751-1
• Mol File: 6345-63-7.mol
• Article Data: 57

Chemical Properties

• Melting Point: 88-90 °C
• Boiling Point: 368.6°Cat760mmHg
• Flash Point: 161.9°C
• Appearance: /
• Density: 1.323g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-nitrobenzylidene di(acetate)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitrobenzylidene di(acetate)(6345-63-7)
• EPA Substance Registry System: 2-nitrobenzylidene di(acetate)(6345-63-7)

Safety Data

• Hazardous Substances Data: 6345-63-7(Hazardous Substances Data)

Usage

General Description

2-Nitrobenzylidene di(acetate) is a chemical compound with the molecular formula C11H9NO6. It is an organic compound that consists of a benzene ring with a nitro group and two acetate groups attached. 2-Nitrobenzylidene di(acetate) is often used as a chemical intermediate in the synthesis of various organic compounds and pharmaceuticals. It is also used as a reagent in organic chemical reactions, and as a building block in the manufacturing of dyes and pigments. 2-Nitrobenzylidene di(acetate) is a solid substance with a yellowish color and has a melting point of around 144 degrees Celsius. It is important to handle this chemical with care as it is potentially hazardous and can cause skin and eye irritation.

InChI:InChI=1/C11H11NO6/c1-7(13)17-11(18-8(2)14)9-5-3-4-6-10(9)12(15)16/h3-6,11H,1-2H3

Upstream product

• 108-24-7 acetic anhydride 
• 99-61-6 3-nitro-benzaldehyde 
• 88-72-2 1-methyl-2-nitrobenzene 
• 114-70-5 sodium phenylacetate 
• 552-89-6 2-nitro-benzaldehyde 
• 7664-93-9 sulfuric acid 
• 581-55-5 benzylidene 1,1-diacetate 
• 116274-79-4 6-(2-Nitro-phenyl)-6,7-dihydro-5H-5,7,7a,13-tetraaza-benzo[3,4]cyclohepta[1,2-b]naphthalen-8-one 

Downstream Products

• 7473-93-0 (E)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one 
• 1427213-33-9 C₁₈H₁₆N₂O₄ 
• 20939-77-9 2-acetamidobenzyl alcohol 
• 571903-49-6 5-acetyl-6-methyl-3,4-dihydro-4-(2-nitrophenyl)pyrimidin-2(1H)-one 
• 17994-61-5 3,4-dihydro-5-ethoxycarbonyl-4-(2-nitrophenyl)-6-methylpyrimidine-2(1H)-one 
• 555-16-8 4-nitrobenzaldehdye 
• 552-89-6 2-nitro-benzaldehyde 
• 94005-04-6 2-nitro-2'.4'.6'-trimethyl-trans-chalcone 

Relevant articles and documents

Chemoselective synthesis of 1,1-diacetates under solvent-free condition using efficient heterogeneous ecofriendly catalyst: P2O5/kaolin

An efficient and chemoselective method for the preparation of acylals from different aldehydes and acetic anhydride using.....kaolin supported catalyst (P2O5). under solvent-free conditions is described herein. The present protocol offers several advantages including use of inexpensive and non-toxic catalyst support i.e., natural kaolin. Preparation of the supported catalyst is easy, the process is simple in operation, maintaining solvent free conditions, with short reaction times, high yields and affording selective protection of aldehyde in presence of ketone.

Supported N-propylsulfamic acid onto Fe3O4 magnetic nanoparticles as a reusable and efficient nanocatalyst for the protection/deprotection of hydroxyl groups and protection of aldehydes

N-propylsulfamic acid supported onto Fe3O4 magnetic nanoparticles (MNPs-PSA) as an efficient and magnetically reusable nanocatalyst has been reported for the tetrahydropyranylation/depyranylation of a wide variety of alcohols and phenols by changing the solvent medium. Also, the protection of aldehydes as acylals using Ac2O in the presence of catalytic amount MNPs-PSA in good to high yields at room temperature under solvent-free conditions is described. After completing the reaction, the catalyst was easily separated from the reaction mixture with the assistance of an external magnetic field and reused for several consecutive runs without significant loss of their catalytic efficiency.

Zinc zirconium phosphate as an efficient catalyst for chemoselective synthesis of 1,1-diacetates under solvent-free conditions

In the present study, a mild, rapid, and efficient method for the protection of aldehydes with acetic anhydride (AA) in the presence of zinc zirconium phosphate (ZPZn) as a nano catalyst, at room temperature is reported. Selective conversion of aldehydes was observed in the presence of ketones. Under these conditions, different aldehydes bearing electron-withdrawing and electron-donating substituents were reacted with AA and the corresponding 1,1-diacetates (acylals) were obtained in high to excellent yields. The steric and electronic properties of the different substrates had a significant influence on the reaction conditions. Also, the deprotection of 1,1-diacetates has been achieved using this catalyst in water. This nanocatalyst was characterized by several physico-chemical techniques. It was recovered easily from the reaction mixture, regenerated and reused at least 7 times without significant loss in catalytic activity. This protocol has the advantages of easy availability, stability, reusability of the eco-friendliness, chemoselectivity, simple experimental and work-up procedure, solvent-free conditions and usage of only a stoichiometric amount of AA.