63455-98-1

Upstream product

• 98-88-4 benzoyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 6665-86-7 7-hydroxyflavone 
• 38987-00-7 2,4-dihydroxy-3-allylacetophenone 
• 93-97-0 benzoic acid anhydride 
• 65679-28-9 7-allyloxy-2-phenyl-4H-chromen-4-one 

Downstream Products

• 691008-31-8 2-phenyl-8-(prop-2-en-1-yl)-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Synthesis of Diverse Oxa-Carbocycle-Annulated Flavones Using the Combined Claisen Rearrangement and Ring-Closing Metathesis

A simple and efficient route for the synthesis of oxepine-, oxocine-, oxepinone-, and dioxocine-angularly annulated flavone skeletons has been developed. The combined Claisen rearrangement and the ring-closing metathesis are used as key steps for the construction of C7/C8–C6–C6tricyclic core structures.

A facile synthesis of 2,3-dihydro-2-hydroxymethyl-5-arylfuro[2,3-h][1]benzopyran-7-ones

The reaction of various 7-hydroxyflavones (1) with allyl bromide in potassium carbonate-acetone yielded the corresponding 7-allyloxy derivatives (2). Claisen rearrangement of 2 gives 7-hydroxy-8-allylflavones (3) which on reaction with equimolar quantity of mCPBA in dichloromethane furnish regioselectively 2,3-dihydro-2-hydroxymethyl-5-aryl-furo[2,3-h][1]benzopyran-7-ones (5) in good yields.