63458-55-9

Upstream product

• 98-92-0 nicotinamide 
• 100-54-9 pyridine-3-carbonitrile 

Downstream Products

• 6298-19-7 2-chloro-3-aminopyridine 
• 462-08-8 pyridin-3-ylamine 
• 125583-35-9 N-(10methylpyridinium-3-carbo)iminotriphenylphosphine 
• 125583-34-8 N-(3-pyridylcarbonyl)triphenylphospha-λ⁵-azene 

Relevant academic research and scientific papers

Preparation method of 3-aminopyridine

The present invention relates to the technical field of 3-aminopyridine, and provides a preparation method of 3-aminopyridine. The preparation method comprises: a) allowing a material flow containing a compound represented by formula (I) to flow through a continuous reactor of a high temperature zone, wherein the temperature of the high temperature zone is 70-90 DEG C; b) introducing the material flow at the outlet of the continuous reactor in the step a) into a second reactor in a low-temperature zone, wherein the temperature of the low-temperature zone is not higher than 50 DEG C; and c) separating to obtain a compound as shown in formula (II), namely the product 3-aminopyridine. The material containing the compound shown in the formula (II) flows through the high-temperature zone with the specific temperature range and then enters the low-temperature zone with the specific temperature range to be cooled, so that the content of the product is effectively increased. Meanwhile, the method disclosed by the invention effectively solves the problems of too fast temperature rise and too high production risk during reaction amplification production, so that large-scale industrial production can be safely carried out, the production efficiency is improved, and the cost is reduced.

Pharmacological studies of new oxidants - N-bromonicotinamide and N-chloronicotinamide

The compounds N-broinonicotinainide (NBN), N-chloronicotinamide (NCN) and nicotinamide (NA) have significant effect on locomotor activity when compared to the standard drug. The compounds NBN, NCN and NA did not show a significant enhancing effect on phenobarbital induced narcosis when compared to the standard drug.

Conversion of nucleophilic halides to electrophilic halides: Efficient and selective halogenation of azinones, amides, and carbonyl compounds using metal halide/lead tetraacetate

AlCl3/Pb(OAc)4 and ZnBr2/Pb(OAc) 4 are efficient electrophilic N- and α-C-halogenating agents. A variety of azinones, amides and carbonyl compounds were chemoselectively and regioselectively N-, or α-C-halogenated in good to excellent yield using AlCl3/Pb(OAc)4 and ZnBr2/Pb(OAc)4 in acetonitrile. Georg Thieme Verlag Stuttgart.

PROCESS FOR THE MANUFACTURE OF 2,3-DICHLOROPYRIDINE

A method for preparing 2,3-dichloropyridine is disclosed in which 3-amino-2-chloropyridine is contacted with an alkali metal nitrite in the presence of aqueous hydrochloric acid to form a diazonium salt; and the diazonium salt is subsequently decomposed in the presence of copper catalyst wherein at least about 50% of the copper is the copper(II) oxidation state.