634598-41-7Relevant academic research and scientific papers
Base-promoted ring contraction of eight-membered cyclic acyloins and their ethers to Cs-symmetric α-ketols
Vilotijevic, Ivan,Yang, Jiong,Hilmey, David,Paquette, Leo A.
, p. 1872 - 1874 (2003)
In the presence of potassium hexamethyldisilazide and 18-crown-6 in THF at room temperature, 2-benzyloxycyclooctanone and its Δ 5-unsaturated congener undergo a two-stage rearrangement to give symmetrical seven-membered ring products. The pathw
Chemical consequences of the ground-state conformations of cyclooctyl rings. Examples of reactivity differences in α-hydroxy and α,α′-dihydroxy eight-membered cyclic ketones
Paquette, Leo A.,Hartung, Ryan
, p. 1201 - 1208 (2007/10/03)
A program directed toward the elucidation of various conformational factors that control reactivity differences in cyclooctyl and cyclooctenyl systems is described. This overview reports on the divergent reactivity observed in the alkylation of saturated
