63460-40-2

Upstream product

• 5891-21-4 5-chloro-2-pentanone 
• 1074-82-4 potassium phtalimide 
• 63460-33-3 5-(4-chloro-phenoxy)-6-methoxy-8-nitro-quinoline 
• 64992-86-5 5-chloro-6-methoxy-8-nitro-quinoline 
• 85-81-4 6-methoxy-8-nitroquinoline 
• 3197-25-9 2-(4-oxopentyl)isoindole-1,3-dione 
• 63460-37-7 5-(4-chloro-phenoxy)-6-methoxy-quinolin-8-ylamine 
• 59353-62-7 4-bromo-1-phthalimidopentane 

Downstream Products

• 57514-26-8 N⁴-(6-methoxy-5-(4-chlorophenoxy)quinolin-8-yl)pentane-1,4-diamine 

Relevant academic research and scientific papers

5-phenoxy primaquine analogs and the tetraoxane hybrid as antimalarial agents

The rapid emergence of drug resistance to the current antimalarial agents has led to the urgent need for the discovery of new and effective compounds. In this work, a series of 5-phenoxy primaquine analogs with 8-aminoquinoline core (7a–7h) was synthesize

Process for production of 8-NHR quinolines

An improved process for producing 8-NHR quinolines from 8-aminoquinolines disclosed. The process comprises reacting 8-aminoquinolines with a substituted alkyl halide in the presence of an amine having a boiling point of 80°-90° C. The amine functions as an acid acceptor whereby the amine salt formed may be efficiently separated from the 8-NHR quinoline formed without expensive or time consuming purification steps. The reaction may be carried out in the presence of a solvent such as an alcohol.