634610-71-2

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 479541-43-0 (3S,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)hexahydrofuro[3,2-b]furan-3-ol 
• 641-74-7 1,4:3,6-dianhydro-D-mannitol 
• 479541-48-5 (3R,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)hexahydrofuro[3,2-b]furan-3-ol 
• 652-67-5 Isosorbide 

Downstream Products

• 634610-73-4 2-O-(4'-cyanophenyl)-5-O-(3''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole 

Relevant academic research and scientific papers

Dianhydrohexitole-based benzamidines: An efficient synthesis of new factor Xa inhibitors

Dianhydrohexitole-based benzamidines were synthesised as potential factor Xa inhibitors. The key steps for the synthesis of a bis-benzamidine series were nucleophilic aromatic substitutions and Mitsunobu reactions to introduce substituted phenyl ether moi

Synthesis of dianhydrohexitole-based benzamidines as factor xa inhibitors using cross couplings, phenyl ether and amidine formations as key steps

Starting with isosorbide or isomannide several dianhydrohexitole-based benzamidines were synthesized as potential factor Xa inhibitors. The key steps for the synthesis of the bisbenzamidines were nucleophilic aromatic substitutions and Mitsunobu reactions