634612-37-6Relevant academic research and scientific papers
CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
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Paragraph 0427; 0431-0433, (2021/11/13)
The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
Proton-exchanged montmorillonite-mediated reactions of hetero-benzyl acetates: Application to the synthesis of Zafirlukast
Yang, Lei,Chen, Xuan,Ni, Kaidong,Li, Yuansheng,Wu, Jianhong,Chen, Weilin,Ji, Yin,Feng, Lili,Li, Fei,Chen, Dongyin
supporting information, (2020/06/28)
Proton-exchanged montmorillonite (H-mont) with outstanding surface characteristics can provide abundant acidic sites in the mesopores, and serve as an efficient heterogeneous catalyst for the synthesis of heterocycle-containing diarylmethanes via Friedel-Crafts-like alkylation of (hetero)arenes by heterobenzyl acetates under mild reaction conditions without requiring any additives or an inert atmosphere. Using this strategy, the gram-scale synthesis of indole-containing diarylmethane 13 has been accomplished in good yield for the preparation of Zafirlukast. In addition, H-mont can be applied to the nucleophilic substitution reactions of heterobenzyl acetate 5p with a variety of alcohols and 1,3-dicarbonyl compounds.
Synthesis of 3-substituted pyrrole derivatives with oligo(ethylene glycol) chains
Zhu, Jie-Wen,Chen, Hai-Bao
, p. 2315 - 2321 (2007/10/03)
An etherification method via alkoxymethyleniminium salt is described. Three pyrrole derivatives with oligo(ethylene glycol) chains at the 3-position were synthesized for the first time using the above method as the key step.
