Welcome to LookChem.com Sign In|Join Free
  • or
TBPB, also known as 3,3'-Bis(trifluoromethyl)diphenylborane, is a synthetic organic compound with a unique structure that allows it to selectively activate the M1 muscarinic acetylcholine receptor. This receptor plays a crucial role in various physiological processes, including cognitive function and memory. TBPB's ability to modulate this receptor makes it a promising candidate for the development of novel therapeutic agents.
Source:
TBPB is synthesized through a series of chemical reactions involving the formation of diphenylborane and subsequent trifluoromethylation.
Production Methods:
The synthesis of TBPB typically involves the reaction of diphenylborane with trifluoroacetic anhydride, followed by a reduction step to obtain the desired compound.

634616-95-8

Post Buying Request

634616-95-8 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

634616-95-8 Usage

Uses

Used in Pharmaceutical Industry:
TBPB is used as an allosteric M1 muscarinic acetylcholine receptor activator for its potential therapeutic effects on cognitive disorders. Its ability to regulate amyloid processing and produce antipsychotic-like activity in rats suggests that it may have applications in the treatment of Alzheimer's disease and other neurodegenerative disorders.
Used in Research Applications:
TBPB is also used as a research tool to study the function and modulation of the M1 muscarinic acetylcholine receptor. This can help scientists better understand the receptor's role in cognitive processes and identify potential targets for the development of new drugs to treat cognitive disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 634616-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,4,6,1 and 6 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 634616-95:
(8*6)+(7*3)+(6*4)+(5*6)+(4*1)+(3*6)+(2*9)+(1*5)=168
168 % 10 = 8
So 634616-95-8 is a valid CAS Registry Number.

634616-95-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma

  • (SML0453)  TBPB  ≥98% (HPLC)

  • 634616-95-8

  • SML0453-5MG

  • 1,041.30CNY

  • Detail

  • Sigma

  • (SML0453)  TBPB  ≥98% (HPLC)

  • 634616-95-8

  • SML0453-25MG

  • 4,201.47CNY

  • Detail

634616-95-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[1'-(2-Methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benz imidazol-2-one

1.2 Other means of identification

Product number -
Other names 2-Pyrrolo-1,3,2-dioxa-phospholan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:634616-95-8 SDS

634616-95-8Downstream Products

634616-95-8Relevant academic research and scientific papers

Concise and simple synthesis of M1 allosteric agonist TBPB

Rasheed, Mohammed Abdul,Shaik, Nagul Meera,Nirogi, Ramakrishna

, p. 1796 - 1801 (2013/05/21)

A concise and simple synthesis of M1 allosteric agonist 1-(1′-(2-methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d] imidazol-2(3H)-one (TBPB) using economical and commercially available orthophenylenediamine (O-PDA) and Boc piperidone has been described. The disclosed scheme allows synthesizing more analogs that were otherwise difficult to prepare with the original method. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.

Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

Bridges, Thomas M.,Brady, Ashley E.,Phillip Kennedy,Nathan Daniels,Miller, Nicole R.,Kim, Kwango,Breininger, Micah L.,Gentry, Patrick R.,Brogan, John T.,Jones, Carrie K.,Jeffrey Conn,Lindsley, Craig W.

experimental part, p. 5439 - 5442 (2009/06/02)

This Letter describes the first account of the synthesis and SAR, developed through an iterative analogue library approach, of analogues of the highly selective M1 allosteric agonist TBPB. With slight structural changes, mAChR selectivity was maintained, but the degree of partial M1 agonism varied considerably.

OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION

-

Page 31, (2008/06/13)

This invention relates to selective m1 muscarinic agonist, their use or a formulation thereof in the treatment of glaucoma and/or other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention also relates to t

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 634616-95-8