63468-63-3

Basic information

• Product Name: 2,5-Dihydro-1H-pyrrole hydrochloride
• Synonyms: 2,5-DIHYDRO-1H-PYRROLE HYDROCHLORIDE;3-Pyrroline hydrochloride;1H-Pyrrole, 2,5-dihydro-, hydrochloride;2,5-Dihydro-1H-pyrrole, HCl
• CAS NO: 63468-63-3
• Molecular Formula: C₄H₇N*ClH
• Molecular Weight: 105.57
• Mol File: 63468-63-3.mol
• Article Data: 19

Chemical Properties

• Melting Point: 169.5-171.5 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,5-Dihydro-1H-pyrrole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dihydro-1H-pyrrole hydrochloride(63468-63-3)
• EPA Substance Registry System: 2,5-Dihydro-1H-pyrrole hydrochloride(63468-63-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 63468-63-3(Hazardous Substances Data)

Usage

Uses

2,5-Dihydro-1H-pyrrole, HCl

Upstream product

• 7153-66-4 <(Z)-4-chloro-2-butenyl>ammonium chloride 
• 6147-66-6 diallylamine hydrochloride 
• 6913-92-4 1-benzyl-2,5-dihydro-1H-pyrrole 
• 109-97-7 pyrrole 
• 108-39-4 3-methyl-phenol 
• 132945-75-6 (S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate 
• 95-48-7 ortho-cresol 
• 77484-76-5 cis-3,4-dibromopyrrolidine hydrochloride 

Downstream Products

• 151692-76-1 1-(6-Bromo-1,3-benzodioxol-5-ylcarbonyl)azacyclopent-3-ene 
• 109-96-6 3-Pyrroline 
• 100350-96-7 trans-3,4-dibromopyrrolidine hydrochloride 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 21399-13-3 1-(2,5-dihydro-1H-pyrrol-1-yl)ethan-1-one 
• 90490-64-5 1-(4-methoxyphenyl)-2-(1H-pyrrol-1-yl)ethan-1-one 
• 111185-41-2 1-(2,5-dihydro-1H-pyrrol-1-yl)-2,2,2-trifluoroethanone 

Relevant articles and documents

Synthesis, characterization, and catalytic activity of a ruthenium carbene complex coordinated with bidentate 2-pyridine-carboxylato ligands

The halide and phosphine free complex [(sIMes)(C5H 4N-2-CO2)2RuCHPh] (7) (sIMes = 1,3-dimesitylimidazolidin-2-ylidene) bearing two bidentate 2-pyridinecarboxylato ligands was synthesized from the carbene complex [(sIMes)(PCy 3)(Cl)2RuCHPh] (4) and the silver 2-pyridine-carboxylate (8). The molecular structure of the octahedral complex 7 reveals that the two carboxylato functions are coordinated in cis geometry to the ruthenium center. Catalyst 7 exhibits activity in ring-closing metathesis (RCM) reactions after addition of a cocatalyst (HCl) in dichloromethane as well as in methanol solution.

Preparation method of medical intermediate N-BOC-3-pyrroline

The invention discloses a preparation method of a medical intermediate N-BOC-3-pyrroline. The method comprises the following steps: adding a proper amount of benzylamine, 3-bromopropylene, dichloromethane and an alkaline reagent into a reaction bottle for reaction to obtain an enamine compound; dissolving the enamine compound in dichloromethane, adding a catalyst (Grubbs first generation) for reaction, adding anhydrous sodium sulfate after adding water for layering, and performing suction filtration to obtain mother liquor; adding 1-chloroethyl chloroformate and methanol into the mother liquor, debenzylating to obtain pink solid, adding petroleum ether into the pink solid, pulping, and carrying out suction filtration to obtain 3-pyrroline hydrochloride; and re-dissolving the 3-pyrroline hydrochloride with water, adding an alkaline solution of NaHCO3 and (BOC)2O, stirring and reacting, extracting after the reaction is finished, separating out an organic phase, and drying to obtain a finished product of N-BOC-3-pyrroline. The method is low in raw material cost, simple in process step, high in yield, small in pollution, high in product purity and suitable for industrial production.

A simple and practical preparation of an efficient water soluble olefin metathesis catalyst

This study details homogeneous olefin metathesis in water catalysed by a di-ammonium functionalised Ru-alkylidene complex. A facile gram scale synthesis of an air stable catalyst precursor which can be readily converted to its water soluble derivative is described. The di-ammonium functionalised Ru-alkylidene complex facilitates a range of ring-closing metathesis (RCM) and cross-metathesis (CM) reactions in water.