63479-82-3Relevant academic research and scientific papers
Preparation and antiarthritic activity of new 1,5-diaryl-3-alkylthio-1H-1,2,4-triazoles and corresponding sulfoxides and sulfones
Szilagyi, Geza,Somorai, Tamas,Bozo, Eva,Lango, Jozsef,Nagy, Gabor,et al.
, p. 95 - 101 (2007/10/02)
A series of 1,5-diaryl-3-alkylthio-1H-1,2,4-triazoles and corresponding sulfoxides and sulfones was synthesized and evaluated as antiinflammatory agents in the rat adjuvant induced arthritis assay.Several analogues were found to be more potent than phenyl
On Triazoles. I. The reaction of N-Cyanocarbonimidodithioic Acid Diesters With Hydrazines
Reiter, J.,Somorai, T.,Jerkovich, Gy.,Dvortsak, P.
, p. 1157 - 1164 (2007/10/02)
The reaction of N-cyanocarbonimidodithioic acid di(alkyl and aralkyl)esters with different alkyl-, aralkyl- and aryl hydrazines to yield 1-substituted-3-R-thio-5-amino-1H-1,2,4-triazoles (3) and 2-substituted-3-R-thio-5-amino-2H-1,2,4-triazoles (4) was studied.Isolation of the different types of isomeric pairs of 3 and 4 helped to prove the structure of products obtained which made possible correction of some confusion in the literature.The 3 (R = H) tautomeric structure of the non-substituted derivatives was supported by comparison of their uv and cmr spectra with those of the alkylated and aralkylated derivatives 3 and 4, respectively, again correcting confusion in literature.An hplc determination of the ratio of products 3 and 4 formed in the above reactions with different hydrazines made it possible to prove the mechanism of the reaction.
