63482-89-3Relevant academic research and scientific papers
Protective solutions for organs
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, (2008/06/13)
Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
Synthesis and anti inflammatory activity of 3,3a dihydro 2H,9H isoxazolo[3,2 b] [1,3]benzoxazin 9 ones and related compounds
Reisner,Ludwig,Stiefel,Gister,Meyer,Powell,Sofia
, p. 760 - 766 (2007/10/09)
A series of 3,3a-dihydro-2H,9H-isoxazolo[3,2-b]-[1,3]benzoxazin 9-ones was synthesized and evaluated for anti-inflammatory, antipyretic and analgesic activity. Since many of these compounds exhibited promising activity, particularly in the anti-inflammatory tests, a number of homologous 2,3,4,4a-tetrahydro-10H-1,2-oxazino[3,2-b]-[1,3]benzoxazin 10-ones and one 3,4,5,5a-tetrahydro-2H, 11H-1,2-oxazepino [3,2-b] [1,3]benzoxazin-11-one, the 9-chloro analog, were also prepared and evaluated. The expanded ring members were generally less active than the tricyclic compounds containing the isoxazolidine rng.
