63484-38-8

Upstream product

• 25921-64-6 5-Chloro-2-methoxy-N-(2-(4-nitrophenyl)ethyl)benzamide 
• 29568-33-0 2-methoxy-5-chlorobenzoyl chloride 
• 24954-67-4 2-(p-nitrophenyl)ethylamine 

Downstream Products

• 60302-51-4 2-Methyl-2-{4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]biphenyl-4'-oxy}-propionic acid 
• 60277-46-5 2-Methyl-2-{4-[2(2-methoxy-5-chloro-benzamido)-ethyl]-biphenyl-4'-oxy}-propanol 
• 123271-93-2 5-Chloro-N-(2-{4-[3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indol-1-yl]-phenyl}-ethyl)-2-methoxy-benzamide 
• 60277-39-6 ethyl 2-methyl 2-{4-[-2-(2-methoxy-5-chloro-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate 

Relevant academic research and scientific papers

2,5-substituted benzolsulfonylureas and thioureas methods for the production thereof use thereof and pharmaceutical preparations containing the same

Novel 2,5-substituted benzolsulfonyl ureas and thioureas of formula (I) as illustrated in the disclosure. The compounds are useful active ingredients for medicaments. The compounds of formula (I) act as inhibitors on ATP-sensitive potassium canals and are

Cardioselective KATP channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas

Sulfonylthioureas exhibiting cardioselective blockade of ATP-sensitive potassium channels (KATP channels) were discovered by stepwise structural variations of the antidiabetic sulfonylurea glibenclamide. As screening assays, reversal of rilmaka

Receptor Binding Sites of Hypoglycemic Sulfonylureas and Related benzoic Acids

The blood glucose level lowering activity of benzoic acid, such as p-benzoic acid (HB699, 2), is discussed in terms of binding at putative insulin-releasing receptor sites of pancreatic β cells.The hypoglycemic potencies fuond for synthetic analogues of 2 indicate that high hypoglycemic activity is only found when a carboxyl group or a group that is readily oxidized to carboxyl in vivo, such as methyl, is attached to the aromatic ring of the phenethyl group.It is proposed that this carboxyl group is able to bind at the same receptor site as the SO2NHCONH group of the sulfonylurea drugs, such as tolbutamide (3).The role of the benzamide group in 2 was attributed to protein binding.