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Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-chloro-3,5,6-trifluoropyridine is used as a building block for the synthesis of pharmaceuticals. It serves as an intermediate in the production of compounds used in the treatment of various diseases, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-4-chloro-3,5,6-trifluoropyridine is utilized as a precursor in the synthesis of compounds for agricultural products. It aids in the development of new agrochemicals that can enhance crop protection and yield.
Used in Electronics and Chemical Industries:
2-Amino-4-chloro-3,5,6-trifluoropyridine is also important in the development of materials used in the electronics and chemical industries. Its unique properties make it suitable for creating advanced materials with specific applications in these fields.

InChI:InChI=1/C5H2ClF3N2/c6-1-2(7)4(9)11-5(10)3(1)8/h(H2,10,11)

Upstream product

• 52026-98-9 4-chloro-2,3,5,6-tetrafluoropyridine 

Relevant academic research and scientific papers

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.

MECHANISM FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 4. ACTIVATING INFLUENCES OF RING-NITROGEN AND TRIFLUOROMETHYL IN NUCLEOPHILIC AROMATIC SUBSTITUTION

Rate constants have been measured for the reactions of ammonia with various fluorinated pyridines and diazines in aqueous dioxan at 25 deg C.From the results the activating effects of ring-nitrogen (relative to C-H) and of trifluoromethyl (relative to -H)

N-Halogeno-compounds. Part 7. Synthesis and Iodine-catalysed Rearrangement to 6-Chloroimino-1-azacyclohexadienes of 4-Substituted 2-(Dichloroamino)-3,5,6-trifluoropyridines

Electrophilic chlorination of the fluorinated 2-aminopyridines 4-X*C5F3N*NH2-2 with t-butyl hypochlorite gave the 2-(dichloroamino)-compounds 4-X*C5F3N*NCl2-2; these isomerized to mixtures of the corresponding 3-chloro-6-chloroimino-1-azacyclohexa-1,4- (predominantly) and 5-chloro-6-chloroimino-1-azacyclohexa-1,3-dienes when treated with iodine. 'Spontaneous' formation of 3-chloro-6-chloroimino-2,3,5-trifluoro-4-methyl-1-azacyclohexa-1,4-diene occurred following chlorination (ButOCl) of 2-amino-3,5,6-trifluoro-4-methylpyridine. 3-Chloro-6-chloroimino- 3,5-difluoro-4-X-2-oxo-1-azacyclohex-4-enes (X = H, Me, or Cl) were obtained by displacement of fluorine from the corresponding 3-chloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,4-dienes with water; hydrolysis of 4,5-dichloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,3-diene provided 4,5-dichloro-6-chloroimino-3,5-difluoro-2-oxo-1-azacyclohex-3-ene.Pyrolysis of the 2-(dichloroamino)pyridines 4-X*C5F3N*NCl2-2 gave the azo-compounds 2,2'-2.The 19F n.m.r. spectra of the chloroimino-1-azacyclohexadienes have been analysed.