63489-56-5

Basic information

• Product Name: 2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE
• Synonyms: 2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE;2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE(WXFC0802)
• CAS NO: 63489-56-5
• Molecular Formula: C₅H₂ClF₃N₂
• Molecular Weight: 182.53
• Mol File: 63489-56-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 117-117.5
• Boiling Point: 213.5°C at 760 mmHg
• Flash Point: 82.9°C
• Appearance: /
• Density: 1.666g/cm³
• Vapor Pressure: 0.164mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE(63489-56-5)
• EPA Substance Registry System: 2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE(63489-56-5)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 63489-56-5(Hazardous Substances Data)

Usage

General Description

2-Amino-4-chloro-3,5,6-trifluoropyridine is a chemical compound with the molecular formula C5H2ClF3N2. It is a halogenated pyridine derivative, which means it contains a pyridine ring with a chlorine and three fluorine atoms attached. 2-AMINO-4-CHLORO-3,5,6-TRIFLUOROPYRIDINE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has a wide range of applications, including as an intermediate in the production of compounds used in the treatment of various diseases and in the development of new agricultural products. Additionally, it is important in the development of materials used in the electronics and chemical industries.

InChI:InChI=1/C5H2ClF3N2/c6-1-2(7)4(9)11-5(10)3(1)8/h(H2,10,11)

Upstream product

• 52026-98-9 4-chloro-2,3,5,6-tetrafluoropyridine 

Relevant articles and documents

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.

N-Halogeno-compounds. Part 7. Synthesis and Iodine-catalysed Rearrangement to 6-Chloroimino-1-azacyclohexadienes of 4-Substituted 2-(Dichloroamino)-3,5,6-trifluoropyridines

Electrophilic chlorination of the fluorinated 2-aminopyridines 4-X*C5F3N*NH2-2 with t-butyl hypochlorite gave the 2-(dichloroamino)-compounds 4-X*C5F3N*NCl2-2; these isomerized to mixtures of the corresponding 3-chloro-6-chloroimino-1-azacyclohexa-1,4- (predominantly) and 5-chloro-6-chloroimino-1-azacyclohexa-1,3-dienes when treated with iodine. 'Spontaneous' formation of 3-chloro-6-chloroimino-2,3,5-trifluoro-4-methyl-1-azacyclohexa-1,4-diene occurred following chlorination (ButOCl) of 2-amino-3,5,6-trifluoro-4-methylpyridine. 3-Chloro-6-chloroimino- 3,5-difluoro-4-X-2-oxo-1-azacyclohex-4-enes (X = H, Me, or Cl) were obtained by displacement of fluorine from the corresponding 3-chloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,4-dienes with water; hydrolysis of 4,5-dichloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,3-diene provided 4,5-dichloro-6-chloroimino-3,5-difluoro-2-oxo-1-azacyclohex-3-ene.Pyrolysis of the 2-(dichloroamino)pyridines 4-X*C5F3N*NCl2-2 gave the azo-compounds 2,2'-2.The 19F n.m.r. spectra of the chloroimino-1-azacyclohexadienes have been analysed.