63499-93-4

Upstream product

• 24175-87-9 2-acetoxy-1-phenyl-1propene 
• 103-79-7 1-phenyl-acetone 
• 4436-22-0 1-phenylpropylene oxide 
• 10573-32-7 β-methoxy-β-methylstyrene 
• 2835-06-5 phenylglycin 
• 108-24-7 acetic anhydride 
• 110-86-1 pyridine 

Downstream Products

• 20662-92-4 2,5-dimethyl-4-phenyloxazole 
• 32187-27-2 1-amino-1-phenylpropan-2-one 
• 77086-71-6 3-acetamido-3-phenyl-3-(Octa-2',7'-dienyl)propan-2-one 
• 77086-72-7 N-((3E,8E)-1-Acetyl-5-but-3-enyl-1-phenyl-trideca-3,8,12-trienyl)-acetamide 

Relevant academic research and scientific papers

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

MONO ET DIFLUORATION ELECTROCHIMIQUES DE GROUPES BENZYLIQUES

Anodic oxidation of benzylic compounds 1 using CH3CN as a solvent and Et3N,3HF as a fluorinating reagent allowed to introduce a fluorine atom in α position of electron withdrawing group via carbocation 1+ (ECBECN mechanism).Whatever the E group, monofluorides 2 are obtained in good yields from paramethoxy derivatives 1 (R=p-OCH3).In this case, by raising the potential of working electrode after the monofluorination step, gem difluorides 3 can be directly prepared from 1.When the substituent of the phenyl ring is different of a methoxy group, a mixture of fluoride 2 and acetamide 4 is generally obtained and the ratio of these two compounds is related to cation stability.

NOUVELLE METHODE DE PREPARATION DE CETONES, ESTER ET NITRILE BENZYLIQUES α-FLUORES OU α,α-DIFLUORES

By anodic oxidation in CH3CN/Et3N, 3HF benzylic ketones, ester and nitrile yield specifically corresponding monofluoro or difluoro compounds.The reaction proceeds through an α-carbonyl or an α-cyano carbocation.

Obtention d'α-fluorocetones par oxydation anodique de derives d'enol.

To obtain fluoroketones without the use of electrophilic fluorinating reagents, we have carried out the anodic oxidation of enol esters and enol ethers in acetonitrile/Et3N, 3HF solution.With enol esters the main product is a fluoroketone or an acetoxyketone respectively, depending on the structure of the starting compound.The enol ether cation-radicals seemed to be less reactive towards H2F3- ions than the corresponding enol ester ones.