63506-72-9Relevant academic research and scientific papers
Variability of Rhodium(III)-Catalyzed Reactions of Aromatic Oximes with Alkenes
Chusov, Denis,Komarova, Alina A.,Perekalin, Dmitry S.,Trifonova, Evgeniya A.
, p. 1117 - 1120 (2020)
Acetophenone oxime reacts with various alkenes in the presence of the rhodium catalyst [Cp*RhCl 2 ] 2 (2.5 molpercent; Cp? = pentamethylcyclopentadienyl) and 1,1,1,3,3,3-hexafluoropropan-2-ol as an important cosolvent. Styrene, aliphatic terminal alkenes, and strained cyclic alkenes gave the corresponding substituted dihydroisoquinolines in yields of 50-99percent. On the other hand, alkenes containing functional groups close to the double bond gave a variety of different products. The reactions of acetophenone oxime with styrene or dec-1-ene in the presence of the chiral catalyst [(C 5 H 2 t Bu 2 CH 2 t Bu)RhI 2 ] 2 provided the corresponding dihydroisoquinolines with improved regioselectivity but a low enantiomeric ratio (61:39 in both cases).
