63519-71-1

Upstream product

• 63476-12-0 2-p-acetylphenyl-1-propyl acetate 
• 10402-52-5 2-phenylpropyl acetate 
• 13329-40-3 4-Iodoacetophenone 
• 107-18-6 allyl alcohol 
• 1123-85-9 (RS)-2-phenyl-1-propanol 
• 34713-70-7 2-Phenylpropanal 

Downstream Products

• 62835-96-5 2-(4-Ethylphenyl)-1-propanol 
• 94474-94-9 2-p-acetylphenyl-1-propyl methyl ether 
• 94474-96-1 2-p-ethylphenyl-1-propyl acetate 
• 94474-91-6 2-p-ethylphenyl-1-propyl methyl ether 
• 94474-92-7 2-p-acetoxyphenyl-1-propyl methyl ether 
• 129379-53-9 1-Chloro-2-(4-acetylphenyl)propane 
• 103867-52-3 1-(1-methyl-2-bromoethyl)-4-acetylbenzene 
• 129379-56-2 1-Iodo-2-(4-acetylphenyl)propane 
• 41387-29-5 2-[4-(acetyl)phenyl] propanoic acid 

Relevant academic research and scientific papers

Practical Intermolecular Hydroarylation of Diverse Alkenes via Reductive Heck Coupling

The hydroarylation of alkenes is an attractive approach to construct carbon-carbon (C-C) bonds from abundant and structurally diverse starting materials. Herein we report a palladium-catalyzed reductive Heck hydroarylation of aliphatic and heteroatom-substituted terminal alkenes and select internal alkenes with an array of (hetero)aryl iodides. The reaction is anti-Markovnikov selective with terminal alkenes and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Additionally, applications of this method to complex molecule diversifications are demonstrated. Mechanistic experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C-H reductive elimination cascade to afford the saturated product and turn over the cycle.

THE EFFECT OF para-SUBSTITUENTS ON THE CONFORMATIONAL BEHAVIOUR OF AROMATIC SIDECHAINS

Proton nmr data are reported for some 2-aryl-1-propyl methyl esters, 2-aryl-1-propyl acetates and trifluoroacetates, 2-aryl-1-propanols and 4-aryl-2,2-dimethylpentanes.The vicinal coupling constants show that there is an increasing population of gauche Aryl/OR rotamers in the first three series (R = Me, R = COMe and R = COCF3) as electron donor groups on the aromatic ring are replaced by electron withdrawing groups.The results are ascribed to a gauche Aryl --- O interaction, the possible origins of which are discussed.