635288-63-0Relevant academic research and scientific papers
Discovery of a novel series of Notch-sparing γ-secretase inhibitors
Kreft, Anthony,Harrison, Boyd,Aschmies, Suzan,Atchison, Kevin,Casebier, David,Cole, Derek C.,Diamantidis, George,Ellingboe, John,Hauze, Diane,Hu, Yun,Huryn, Donna,Jin, Mei,Kubrak, Dennis,Lu, Peimin,Lundquist, Joseph,Mann, Charles,Martone, Robert,Moore, William,Oganesian, Aram,Porte, Alex,Riddell, Dave R.,Sonnenberg-Reines, June,Stock, Joseph R.,Sun, Shaiu-Ching,Wagner, Erik,Woller, Kevin,Xu, Zheng,Zhou, Hua,Steven Jacobsen
scheme or table, p. 4232 - 4236 (2009/04/10)
Using a cell-based assay, we have identified a new series of Notch-sparing γ-secretase inhibitors from HTS screening leads 2a and 2e. Lead optimization studies led to the discovery of analog 8e with improved γ-secretase inhibitory potency and Notch-sparing selectivity.
SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION
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Page 41-42, (2010/02/06)
Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer’s Disease and Down’s syndrome are described.
