635291-65-5

Upstream product

• 501-53-1 benzyl chloroformate 
• 193945-92-5 (3,4-dihydro-2H-pyrazol-3-yl)-(10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone 

Downstream Products

• 635291-78-0 (S)-2-[(2S,3S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-hydroxy-3-phenyl-pentanoyl]-pyrazolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 
• 635291-74-6 methyl (3S)-2-{(2S,3S)-3-cyclohexyl-2-[(trifluoroacetyl)amino]pent-4-enoyl}-1-benzyloxycarbonylpyrazolidine-3-carboxylate 
• 635291-70-2 methyl 1-benzyloxycarbonyl-2-[2-(1,3-di-oxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpent-4-enoyl]pyrazolidine-3-carboxylate 
• 635291-76-8 methyl (3S)-2-[(2S,3S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenyl-5-oxopentanoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate 
• 635291-67-7 methyl 2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)pent-4-enoyl]-1-benzyloxycarbonylpyrazolidine-3-carboxylate 
• 635291-66-6 3-methyl 1-(phenylmethyl) (3S)-1,3-pyrazolidinedicarboxylate 

Relevant academic research and scientific papers

Constrained peptidomimetics: Building bicyclic analogs of pyrazoline derivatives

A synthetic route has been developed for incorporating pyrazoline derivatives as proline surrogates in constrained X-Pro peptidomimetics. The route allows for the synthesis of dipeptide building blocks having either a six or seven-membered-ring annulated