635313-39-2

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 850166-76-6 (R)-(1-(4-methoxyphenyl)-2-oxoethyl) tert-butyl carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 57591-61-4 methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 159848-74-5 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate 
• 193073-85-7 methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate 

Downstream Products

• 220736-25-4 (4R,5R)-cytoxazone 
• 220736-25-4 (4R,5S)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one 
• 383420-35-7 (2R,3R)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1,2-propanediol 
• 700359-87-1 [3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-1-(4-methoxy-phenyl)-propyl]-carbamic acid tert-butyl ester 
• 635313-42-7 3R-(tert-butoxycarbonyl)-amino-3-(4-methoxyphenyl)-2S-propane-1-(tert-butyl dimethylsiloxy)-2-ol 
• 635313-43-8 2R-amino-1-(tert-butyldimethylsiloxy)methyl-2-(4-methoxyphenyl)-(1R)-ethyl 4-nitrobenzoate 
• 635313-40-5 (4R,5R)-5-(ethenyl)-4-(4-methoxyphenyl)-2-oxazolidinone 
• 635313-41-6 (2S,3R)-3-tert-butoxycarbonylamino-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol 

Relevant academic research and scientific papers

Stereoselective synthesis of (-)-cytoxazone and (+)-5-epi-cytoxazone

A novel, stereo selective synthesis of (-)-cytoxazone 1a and stereoselective synthesis of (+)-5-epi-cytoxazone 1b were achieved via stereoselective Grignard addition of vinylmagnesium bromide on N-Boc aldehyde obtained from p-hydroxy-D-phenylglycine 2 followed by cyclization of N-Boc alcohol 6, ozonolysis and reduction to get (+)-5-epi-cytoxazone. Compound 6 underwent mitsunobu conditions, deprotection of ester followed by cyclization of N-Boc alcohol to get (-)-cytoxazone.