635319-10-7Relevant articles and documents
Synthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase
Evans, Gary B.,Furneaux, Richard H.,Lewandowicz, Andrzej,Schramm, Vern L.,Tyler, Peter C.
, p. 5271 - 5276 (2007/10/03)
Purine nucleoside phosphorylases (PNPs) catalyze nucleophilic displacement reactions by migration of the cationic ribooxacarbenium carbon between the fixed purine and phosphate nucleophiles. As the phosphorolysis reaction progresses along the reaction coo