666830-86-0

Upstream product

• 635319-15-2 7-(3-benzyloxy-4-benzyloxymethyl-pyrrolidin-1-ylmethyl)-5-benzyloxymethyl-4-tert-butoxy-5H-pyrrolo[3,2-d]pyrimidine 
• 299916-78-2 7-N-benzyloxymethyl-9-bromo-6-O-tert-butyl-9-deaza-hypoxanthine 
• 635319-09-4 tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 635319-12-9 7-benzyloxymethyl-6-O-tert-butyl-9-deaza-9-formylhypoxanthine 
• 635319-10-7 (3R,4R)-N-tert-butoxycabonyl-3-benzyloxy-4-benzyloxymethylpyrrolidine 

Downstream Products

• 666830-87-1 (3R,4R)-1-[(9-deaza-7-benzyloxymethyl-adenin-9-yl)methyl]-3-benzyloxy-4-(benzyloxymethyl)pyrrolidine 

Relevant academic research and scientific papers

INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES

The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds

Synthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase

Purine nucleoside phosphorylases (PNPs) catalyze nucleophilic displacement reactions by migration of the cationic ribooxacarbenium carbon between the fixed purine and phosphate nucleophiles. As the phosphorolysis reaction progresses along the reaction coo