63540-08-9Relevant academic research and scientific papers
Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides
Bellucci, Maria Cristina,Sacchetti, Alessandro,Volonterio, Alessandro
supporting information, p. 705 - 715 (2019/10/02)
A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N′-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 Nα-substituted-N4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.
Nucleophilic Substitution on Dialkoxy Disulfides. III. Reaction with Thioureas
Kagami, Hiroaki,Hanzawa, Takashi,Suzuki, Nobuo,Yamaguchi, Shoso,Saito, Masami,Motoki, Shinichi
, p. 3658 - 3660 (2007/10/02)
1,3- and 1,1-Disubstituted thioureas reacted with diethoxy disulfide to give carbodiimides and 1,2,4-thiadiazoles respectively. 1,1,3-Trisubstituted thioureas and diethoxy disulfide afforded trialkyl(trialkylamidino)thioureas.
