63547-25-1

Basic information

• Product Name: Modafinil Carboxylate Methyl Ester
• Synonyms: Methyl (benzhydrylsulfinyl)acetate;2-[(Diphenylmethyl)sulfinyl]acetic Acid Methyl Ester;Modafinil Carboxylate Methyl Ester;(Benzhydrylsulfinyl)acetic acid methyl ester;2-(Benzhydrylsulfinyl)acetic acid methyl ester;Acetic acid, 2-[(diphenylMethyl) sulfinyl]-, Methyl ester;methyl 2-(benzhydrylsulfinyl)acetate;Modafinil EP impurity C
• CAS NO: 63547-25-1
• Molecular Formula: C₁₆H₁₆O₃S
• Molecular Weight: 288.365
• Product Categories: Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 63547-25-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 85-87°C
• Boiling Point: 483.787°C at 760 mmHg
• Flash Point: 246.386°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: -20?C Freezer
• CAS DataBase Reference: Modafinil Carboxylate Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Modafinil Carboxylate Methyl Ester(63547-25-1)
• EPA Substance Registry System: Modafinil Carboxylate Methyl Ester(63547-25-1)

Safety Data

• Hazardous Substances Data: 63547-25-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless Oil

Uses

Modafinil derivative

InChI:InChI=1/C16H16O3S/c1-19-15(17)12-20(18)16(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11,16H,12H2,1H3

Upstream product

• 101-81-5 Diphenylmethane 
• 91-01-0 1,1-Diphenylmethanol 
• 67-56-1 methanol 
• 63547-24-0 modafinil acid 
• 77-78-1 dimethyl sulfate 
• 79-22-1 methyl chloroformate 

Downstream Products

• 112111-43-0 Modafinil 
• 1726-02-9 bis(diphenylmethyl)disulfide 

Relevant articles and documents

Nickel-catalyzed oxidative dehydrogenative coupling of alkane with thiol for C(sp3)-S bond formation

A nickel-catalyzed oxidative dehydrogenative coupling reaction of alkane with thiol for the construction of C(sp3)-S bond has been established, affording more than 50 alkyl thioethers. Notably, pharmaceutical and agrochemicals, such as Provigil, Chlorbenside and Pyridaben, were readily synthesized by this approach. The sterically hindered ligand BC and disulfide which was formed in situ oxidation of thiol, efficiently avoiding nickel-catalyst poisoning. A set of mechanistic experiments disclose both Ni-catalyzed and Ni-free HAA processes.

AN IMPROVED PROCESS FOR THE PREPARATION OF ARMODAFINIL

The invention encompasses processes for preparing intermediates, such as R-modafinic acid or (R)-C1-2 alkyl ester, of modafinic acid, and the conversion of the intermediates to armodafinil.

Novel method for preparing methyl 2-diphenylmethylsulfinylacetate

Method for preparing methyl 2-diphenylmethylsulfinylacetate (MDMSA) comprising the steps of :(i) conversion of benzhydrol into methyldiphenylmethylthioacetate ; and(ii) conversion of methyldiphenylmethylthioacetate into methyl-2-diphenylmethylsulfinylacet