63554-21-2Relevant academic research and scientific papers
Identifying specific conformations by using a carbohydrate scaffold: Discovery of subtype-selective LPA-receptor agonists and an antagonist
Tamaruya, Yoko,Suzuki, Masato,Kamura, Goshu,Kanai, Motomu,Hama, Kotaro,Shimizu, Kumiko,Aoki, Junken,Arai, Hiroyuki,Shibasaki, Masakatsu
, p. 2834 - 2837 (2007/10/03)
Stable and potent subtype-selective lysophosphatidic acid (LPA) analogues (agonists and an antagonist) were developed by using carbohydrates as a core structure (see scheme). An array of molecules with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen-bond acceptor) attached to carbohydrate isomers in different three-dimensional arrangements were tested for LPA-receptor activation or inhibition. R = alkyl.
Stereoselective entry to β-linked C-disaccharides using a carbon-ferrier reaction
Gemmell, Natasha,Meo, Paul,Osborn, Helen M. I.
, p. 1649 - 1652 (2007/10/03)
(Matrix presented) The synthesis of unsaturated β-linked C-disaccharides by the Lewis acid-mediated reaction of 3-O-acetylated glycals with monosaccharide-derived alkenes is described. Deprotection and selective hydrogenation of an exocyclic carbon-carbon
Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones
Masumoto, Shuji,Yabu, Kazuo,Kanai, Motomu,Shibasaki, Masakatsu
, p. 2919 - 2922 (2007/10/03)
A practical and more environmentally benign synthetic route of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones is described. A key step is the regioselective SN2 reaction to cyclic sulfate 12 with catech
