63556-12-7 Usage
Uses
Used in Pharmaceutical Industry:
N-(3-aminophenyl)nicotinamide is used as a therapeutic agent for its potential role as an inhibitor of poly (ADP-ribose) polymerase (PARP), which is involved in DNA repair and cell survival. This makes it a promising candidate for the development of drugs targeting cancer treatment.
Used in Cancer Research:
N-(3-aminophenyl)nicotinamide is used as an anti-tumor and anti-angiogenic agent, as it has been implicated in cancer research for its potential to inhibit tumor growth and angiogenesis, the formation of new blood vessels that supply nutrients to tumors.
Used in Neurodegenerative Disease Treatment:
N-(3-aminophenyl)nicotinamide is used as a neuroprotective agent, as it has been investigated for its potential to treat neurodegenerative diseases by protecting neurons and reducing the damage caused by oxidative stress and other harmful factors.
Check Digit Verification of cas no
The CAS Registry Mumber 63556-12-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,5,5 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 63556-12:
(7*6)+(6*3)+(5*5)+(4*5)+(3*6)+(2*1)+(1*2)=127
127 % 10 = 7
So 63556-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H11N3O/c13-10-4-1-5-11(7-10)15-12(16)9-3-2-6-14-8-9/h1-8H,13H2,(H,15,16)
63556-12-7Relevant academic research and scientific papers
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold
Flaherty, Daniel P.,Simpson, Denise S.,Miller, Melissa,Maki, Brooks E.,Zou, Beiyan,Shi, Jie,Wu, Meng,McManus, Owen B.,Aubé, Jeffrey,Li, Min,Golden, Jennifer E.
, p. 3968 - 3973 (2014/09/03)
TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.
