63558-84-9

Usage

Uses

Used in Pharmaceutical Industry:
7-Chlorobenzofuran-2-carboxylic acid is used as a reactant in the preparation of (pyridopyrimidinylalkyl)benzofuropyridines, which are compounds with α1-antagonistic and antidepressant activities. Its incorporation into these molecules contributes to their therapeutic properties, making it a valuable component in the development of novel treatments for various medical conditions.

Upstream product

• 1927-94-2 3-chlorosalicylaldehyde 
• 685-87-0 Diethyl 2-bromomalonate 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 
• 260273-62-9 ethyl 7-chlorobenzofuran-2-carboxylate 

Downstream Products

• 24410-55-7 7-chloro benzo[b]furan 

Relevant academic research and scientific papers

GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

The synthesis and biological activity of a series of benzofuro[3,2- c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the α2-adrenoceptor, with high selectivity versus the α1-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation.