63563-93-9Relevant academic research and scientific papers
Palladium-Catalyzed ortho-C(sp2)-H Silylation of Aromatic Ketones Using an Aminooxyamide Auxiliary
Li, Jianhua,Ding, Meiying,Jiang, Chao
supporting information, p. 9036 - 9040 (2021/11/24)
A palladium-catalyzed direct and selective ortho-C(sp2)-H silylation of aromatic ketones has been achieved using an aminooxyamide auxiliary. The reaction tolerates various orth-, meta-, and para- substituents on the aromatic ring and can be applied to thi
Cp?-Free Cobalt-Catalyzed C-H Activation/Annulations by Traceless N, O-Bidentate Directing Group: Access to Isoquinolines
Li, Xiao-Cai,Du, Cong,Zhang, He,Niu, Jun-Long,Song, Mao-Ping
, p. 2863 - 2866 (2019/04/17)
N,O-Bidentate directing-enabled, traceless heterocycle synthesis is described via Cp?-free cobalt-catalyzed C-H activation/annulation. The weakly coordinating nature of the carboxylic acid was employed for the preparation of isoquinolines. Meanwhile, the N-O bond of the α-imino-oxy acid can serve as an internal oxidant. Terminal as well as internal alkynes can be efficiently applied to the catalytic system. This operationally simple approach shows a broad substrate scope with the products obtained in good to excellent yields.
Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base
Kosmalski, Tomasz,Studzińska, Renata,Daniszewska, Natalia,Ullrich, Ma?gorzata,Sikora, Adam,Marsza??, Micha?,Modzelewska-Banachiewicz, Bo?ena
, p. 551 - 557 (2018/08/17)
In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base—pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2 min to 3 h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using 1H NMR and 13C NMR spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.
Photoredox Imino Functionalizations of Olefins
Davies, Jacob,Sheikh, Nadeem S.,Leonori, Daniele
supporting information, p. 13361 - 13365 (2017/10/17)
Shown herein is that polyfunctionalized nitrogen heterocycles can be easily prepared by a visible-light-mediated radical cascade process. This divergent strategy features the oxidative generation of iminyl radicals and subsequent cyclization/radical trapping, which allows the effective construction of highly functionalized heterocycles. The reactions proceed efficiently at room temperature, utilize an organic photocatalyst, use simple and readily available materials, and generate, in a single step, valuable building blocks that would be difficult to prepare by other methods.
