63564-50-1

Upstream product

• 1956-39-4 (E)-1-(4-chlorophenyl)ethanone oxime 
• 57-57-8 β-Propiolactone 
• 28191-82-4 α-methyl-4-chlorobenzylideneaminoxy propionic acid, ethyl ester 

Downstream Products

• 134468-86-3 Sodium; (2S,3S)-3-{3-[1-(4-chloro-phenyl)-eth-(E)-ylideneaminooxy]-propionylamino}-2-methyl-4-oxo-azetidine-1-sulfonate 
• 119881-32-2 (6R,7R)-7-{3-[1-(4-Chloro-phenyl)-eth-(E)-ylideneaminooxy]-propionylamino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 119881-37-7 (6R,7R)-3-Acetoxymethyl-7-{3-[1-(4-chloro-phenyl)-eth-(E)-ylideneaminooxy]-propionylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, antiinflammatory activity and platelet anti-aggregating activity of a new series of β-aminoxypropionic acids

A series of β-aminoxypropionic acids (AOPAs) had previously been designed and synthesised as analogues of antiinflammatory arylacetic acids (ArAAs) in which the Ar portion is substituted by the (methyleneaminoxy) methyl moiety (O = NOCH2, MAOMM

Synthesis and antimicrobial properties of substituted β-aminoxypropionyl penicillins and cephalosporins

Some β-aminoxypropionyl penicillins (3) and cephalosporins (4 and 5), planned on the basis of the hypothesis that the (methyleneaminoxy)methyl group (>C = NOCH2) could be a 'bioisoster' of either aryls or other aromatic groups, were synthesized and assayed for their antimicrobial properties. Compounds 3-5, tested on Gram-positive and Gram-negative bacteria, both sensitive to enzyme inactivation and otherwise, exhibited an activity trend that was not substantially different from that of the corresponding phenylacetamido derivatives taken as terms of comparison.

Oxime ether derivatives, a new class of nonsteroidal antiinflammatory compounds

A series of new 2-hydroxyethyl and carboxyalkyl ethers of aromatic oximes was found to possess pronounced antiinflammatory activity in the carrageenan-induced edema test in the rat. The activity was limited mainly to derivatives of p-haloacetophenone oxime and of p-halobenzaldehyde oxime. Nevertheless the hydroxyethyl and carboxyalkyl groups may be converted into many derivatives with maintenance of activity. Some structure-activity relationships are in contrast to those of the well-known antiinflammatory arylacetic acids. The activity is limited to the E stereoisomers. The hydrochloride of 2-(dimethylamino)ethyl (E)-[[(p-chloro-α- methylbenzylidene)-amino]oxy]acetate (36, INN name Cloximate) was cosen for clinical evaluation. The first results agree with the pharmacological prospects.