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Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate is a complex ester form of 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoylethylamine, which is a local anesthetic and antiarrhythmic medication. Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate has potential applications in medical research, drug development, and the pharmaceutical industry. Due to its potential health hazards, it is important to handle Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate with caution and only in controlled laboratory settings. Further research and evaluation are necessary to fully understand its properties and potential uses.

635678-10-3

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    Cas No: 635678-10-3

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635678-10-3 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate is used as an intermediate in the synthesis of local anesthetics and antiarrhythmic medications for the treatment of various medical conditions.
Used in Medical Research:
Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate is used as a research tool to study the properties and mechanisms of action of local anesthetics and antiarrhythmic medications, contributing to the development of new and improved therapies.
Used in Drug Development:
Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate is utilized in the development of new drugs with potential applications in treating pain and cardiac arrhythmias, enhancing the safety and efficacy of existing treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 635678-10-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,5,6,7 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 635678-10:
(8*6)+(7*3)+(6*5)+(5*6)+(4*7)+(3*8)+(2*1)+(1*0)=183
183 % 10 = 3
So 635678-10-3 is a valid CAS Registry Number.

635678-10-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-amino-5-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]benzoate

1.2 Other means of identification

Product number -
Other names QC-6153

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:635678-10-3 SDS

635678-10-3Relevant articles and documents

QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF

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Paragraph 0060; 0066-0067, (2021/02/18)

Related to a quinazoline compound serving as an EFGR triple mutation inhibitor and applications thereof. Specifically, disclosed are a compound as represented by the following formula (I), a pharmaceutical composition comprising the compound of formula (I

Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S

Li, Qiannan,Zhang, Tao,Li, Shiliang,Tong, Linjiang,Li, Junyu,Su, Zhicheng,Feng, Fang,Sun, Deheng,Tong, Yi,Wang, Xia,Zhao, Zhenjiang,Zhu, Lili,Ding, Jian,Li, Honglin,Xie, Hua,Xu, Yufang

supporting information, p. 869 - 873 (2019/06/08)

In this paper, we describe the discovery and optimization of a series of noncovalent reversible epidermal growth factor receptor inhibitors of EGFRL858R/T790M/C797S. One of the most promising compounds, 25g, inhibited the enzymatic activity of EGFRL858R/T790M/C797S with an IC50 value of 2.2 nM. Cell proliferation assays showed that 25g effectively and selectively inhibited the growth of EGFRL858R/T790M/C797S-dependent cells. This series of compounds, which occupy both the ATP binding site and the allosteric site of the EGFR kinase, may serve as a basis for the development of fourth-generation EGFR inhibitors for L858R/T790M/C797S mutants.

Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: Synthesis of18F-Iressa and related molecular probes

Seimbille, Yann,Phelps, Michael E.,Czernin, Johannes,Silverman, Daniel H. S.

, p. 829 - 843 (2007/10/03)

Inhibitors of tyrosine kinase enzymatic activity represent a promising new class of antineoplastic agents. Although clinical studies performed over the last decade give more insight on the potential therapeutic applications of such drugs, identification of the individual patients who might benefit from them remains a major challenge. We have developed a synthetic strategy for the production of a wide variety of radiolabeled 6,7-disubstituted 4-anilinoquinazolines suitable for noninvasive imaging of tyrosine kinase receptors to predict therapy effectiveness. Three new F-18 labeled radiopharmaceuticals based on the therapeutic agents Tarceva, Iressa, and ZD6474 were synthesized. Decay-corrected yields varied between 25 and 40% for a total synthesis time of 120 min, thus providing F-18 labeled tyrosine kinase inhibitors in quantities and times practical for use as PET radiopharmaceuticals. Copyright

Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity

Boschelli, Diane H.,Ye, Fei,Wu, Biqi,Wang, Yanong D.,Barrios Sosa, Ana Carolina,Yaczko, Deanna,Powell, Dennis,Golas, Jennifer M.,Lucas, Judy,Boschelli, Frank

, p. 3797 - 3800 (2007/10/03)

Several 7-alkoxy-4-anilino-3-quinolinecarbonitriles were synthesized and evaluated for Src kinase inhibitory activity. Optimal inhibition of both Src enzymatic and cellular activity was seen with analogues having a 2,4-dichloro-5-methoxyaniline group at C-4. Compound 18, which has a 1-methylpiperidinemethoxy group at C-7, showed in vivo activity in a xenograft model.

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