Methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate

Base Information

Chemical Name:Methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate
CAS No.:635678-10-3
Molecular Formula:C16H24N2O4
Molecular Weight:308.378
Hs Code.:
DSSTox Substance ID:DTXSID00469178
Wikidata:Q82296779
Mol file:635678-10-3.mol

Synonyms:635678-10-3;methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate;Methyl 2-aMino-5-Methoxy-4-(1-Methylpiperidin-4-ylMethoxy)benzoate;methyl 2-amino-5-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]benzoate;SCHEMBL21473565;DTXSID00469178;C16133

Suppliers and Price of Methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate 95+%
1g
$ 300.00

Alichem
Methyl2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate
5g
$ 490.50

Alichem
Methyl2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate
1g
$ 162.00

Total 6 raw suppliers

Chemical Property of Methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate

Chemical Property:

Boiling Point:445.6±40.0 °C(Predicted)
PKA:9.05±0.10(Predicted)
PSA：74.02000
Density:1.137±0.06 g/cm3(Predicted)
LogP:2.30370
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:308.17360725
Heavy Atom Count:22
Complexity:358

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(CC1)COC2=C(C=C(C(=C2)N)C(=O)OC)OC

Technology Process of Methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate

There total 7 articles about Methyl 2-amino-5-methoxy-4-((1-methylpiperidin-4-yl)methoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 906565-53-5
methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate

: 635678-10-3
methyl 2-amino-5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)benzoate

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; for 6h;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 635678-10-3
methyl 2-amino-5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / triphenylphosphine; diethyl azodicarboxylate / CH₂Cl₂; toluene / 1 h / 20 °C

2: HCl / dioxane / 1 h / 20 °C

3: 80 percent / formic acid / H₂O / 95 °C

4: nitric acid; trifluoroacetic acid / CH₂Cl₂ / 20 °C

5: hydrogen / palladium on activated carbon / methanol

With hydrogenchloride; formic acid; hydrogen; nitric acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; toluene;
DOI:10.1002/jlcr.998

Reference yield:

: 635678-09-0
methyl 3-methoxy-4-(1-methylpiperidin-4-ylmethoxy)benzoate

: 635678-10-3
methyl 2-amino-5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: nitric acid; trifluoroacetic acid / CH₂Cl₂ / 20 °C

2: hydrogen / palladium on activated carbon / methanol

With hydrogen; nitric acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/jlcr.998