635678-66-9Relevant academic research and scientific papers
Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction
Shoji, Mitsuru,Imai, Hiroki,Mukaida, Makoto,Sakai, Ken,Kakeya, Hideaki,Osada, Hiroyuki,Hayashi, Yujiro
, p. 79 - 91 (2007/10/03)
(Chemical Equation Presented). Full details of two versions of the total synthesis of epoxyquinols A, B, and C and epoxytwinol A (RKB-3564D) are described. In the first-generation synthesis, the HfCL4-mediated diastereoselective Diels-Alder rea
Novel non-peptide inhibitors targeting death receptor-mediated apoptosis
Kakeya, Hideaki,Miyake, Yasunobu,Shoji, Mitsuru,Kishida, Satoshi,Hayashi, Yujiro,Kataoka, Takao,Osada, Hiroyuki
, p. 3743 - 3746 (2007/10/03)
We have previously reported that ECH, (2R, 3R, 4S)-2,3-epoxy-4-hydroxy-5-hydroxymethyl-6-(1E)-propenyl-cyclohex-5-en-1-one inhibits Fas-mediated apoptosis by blocking self-activation of pro-caspase-8 in the death-inducing signaling complex (DISC). A series of ECH derivatives were asymmetrically synthesized via key synthetic intermediates obtained from lipase-catalyzed kinetic resolution. Inhibitory activities of the derivatives towards death receptor-mediated apoptosis both in type I and type II cells were investigated, revealing that novel non-peptide inhibitors, RKTS-33 and RKTS-34, are effective as ECH.
Total synthesis of (+)-epoxyquinols A and B
Shoji, Mitsuru,Yamaguchi, Junichiro,Kakeya, Hideaki,Osada, Hiroyuki,Hayashi, Yujiro
, p. 3192 - 3194 (2007/10/03)
A highly stereoselective HfCl4-mediated Diels-Alder reaction of furan and the chiral acrylate ester of Corey's auxiliary to subsequently give 1, and the realization of the postulated biosynthetic pathway for the construction of epoxyquinols A a
