635678-67-0

Upstream product

• 488808-28-2 (1R,2S,4S,5R,7R)-7-(tert-butyldimethylsilanyloxymethyl)-3,8-dioxatricyclo[5.1.0.0^2,4]octan-5-ol 
• 488808-29-3 (1R,5S,6R)-4-(tert-butyldimethylsiloxymethyl)-5-hydroxy-7-oxabicyclo[4.1.0]hept-3-en-2-one 
• 488808-31-7 (4R,6R,7S)-2-iodo-9,9-dimethyl-5,8,10-trioxatricyclo[5.4.0.0^4,6]undec-1-en-3-one 
• 635678-63-6 (1R,2S,4S,5R,7R)-7-hydroxymethyl-3,8-dioxatricyclo[5.1.0.0^2,4]octan-5-ol 
• 488808-27-1 (1S,2R,4S,6R,7S)-4-methoxycarbonyl-3,8-dioxatricyclo[5.1.0.0^2,4]octan-6-ol 
• 488808-30-6 (4R,6R,7S)-9,9-dimethyl-5,8,10-trioxatricyclo[5.4.0.0^4,6]undec-1-en-3-one 
• 635678-66-9 (2R,3R,4S)-2,3-epoxy-4-hydroxy-5-hydroxymethyl-cyclohex-5-en-1-one 
• 78844-86-7 rac-(1R,5R,6S)-3-methoxycarbonyl-7-oxabicyclo[4.1.0]hept-2-en-5-ol 
• 78844-86-7 methyl 3(R),4(R)-epoxy-5(R)-hydroxy-1-cyclohexene-1-carboxylate 
• 635678-64-7 6,6-dimethyl-3-(1-methyl-propenyl)-7a,7b-dihydro-1aH,4H-1,5,7-trioxa-cyclopropa[a]naphthalen-2-one 

Relevant academic research and scientific papers

Novel non-peptide inhibitors targeting death receptor-mediated apoptosis

We have previously reported that ECH, (2R, 3R, 4S)-2,3-epoxy-4-hydroxy-5-hydroxymethyl-6-(1E)-propenyl-cyclohex-5-en-1-one inhibits Fas-mediated apoptosis by blocking self-activation of pro-caspase-8 in the death-inducing signaling complex (DISC). A series of ECH derivatives were asymmetrically synthesized via key synthetic intermediates obtained from lipase-catalyzed kinetic resolution. Inhibitory activities of the derivatives towards death receptor-mediated apoptosis both in type I and type II cells were investigated, revealing that novel non-peptide inhibitors, RKTS-33 and RKTS-34, are effective as ECH.