635679-00-4

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 635678-99-8 2-azido-N,N-diethyl-4,5-O-isopropylidene-3-O-triisopropylsilyl-7-O-trityl-D-glycero-D-allo-heptonamide 

Relevant academic research and scientific papers

Studies on reactivity of azidoamides, intermediates in the synthesis of tetrahydroxypipecolic acid derivatives

Azido group reduction was observed by the treatment of a 2-azido-3-triisopropylsilyloxy heptonamide derivative with NaI in DMSO. The process allowed us to obtain a tetrahydroxypipecolic acid amide derivative. The same azido amide was treated with LiCl in DMSO, but desilylation occurred to give 3,6-anhydro-2-azido heptonamide.

Iminosugars from α,β-epoxyamides. Part 1: Synthetic approach to hydroxylated piperidine derivatives

A new synthetic route towards iminosugars starting from chiral epoxyamides is described. The strategy, by which a single precursor, the α,β-epoxyamide obtained from 6-O-trityl-2, 3-O-isopropylidene-D-ribose and a sulphur ylide, can be transformed into different iminosugars, is based on the combination of a regioselective epoxide opening and stereospecific intramolecular displacements.