635681-46-8Relevant academic research and scientific papers
Synthesis of 2,2- and 2,5-disubstituted 1-oxyl pyrrolidine radicals as new homobifunctional cross-linking spin labels
Kalai, Tamas,Jeko, Jozsef,Hubbell, Wayne L.,Hideg, Kalman
, p. 2084 - 2088 (2003)
The synthesis of 2,2- and 2,5-disubstituted pyrrolidine nitroxide radicals starting from readily available nitrones 1, 11 is described. The stable radicals are acylating (10, 20), alkylating (7, 17) and thiol-specific (8, 18) reagents capable of producing cross-links in proteins over distances in the range of 10-15 A.
