635684-69-4

Upstream product

• 4163-60-4 β-D-galactose peracetate 
• 3150-20-7 4-methoxyphenyl β-D-galactopyranoside 
• 159922-68-6 4-methoxyphenyl 2,6-di-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranoside 
• 159922-50-6 4-methoxyphenyl 2,6-di-O-benzyl-β-D-galactopyranoside 
• 159922-67-5 4-methoxyphenyl 3,4-O-isopropylidene-β-D-galactopyranoside 
• 2872-65-3 4-methoxyphenyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 
• 169557-99-7 2,3,4-tri-O-benzoyl-1-deoxy-1-(2,2,2-trichloro-1-iminoethoxy)-α-D-glucopyranuronate, methyl ester 
• 635684-68-3 4-methoxyphenyl 4-O-benzoyl-2,6-di-O-benzyl-β-D-galactopyranoside 

Downstream Products

• 635684-70-7 (2S,3S,4S,5R,6R)-3,4,5-Tris-benzoyloxy-6-[(2R,3S,4S,5R,6R)-3,5-bis-benzoyloxy-2-benzoyloxymethyl-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 635684-78-5 (2S,3S,4S,5R,6R)-3,4,5-Tris-benzoyloxy-6-[(2R,3S,4S,5R,6S)-3,5-bis-benzoyloxy-2-benzoyloxymethyl-6-(4-methoxy-phenoxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 635684-77-4 (2S,3S,4S,5R,6R)-3,4,5-Tris-benzoyloxy-6-[(2R,3S,4R,5R,6S)-3-benzoyloxy-5-hydroxy-2-hydroxymethyl-6-(4-methoxy-phenoxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

CARBOHYDRATE LIGANDS THAT BIND TO IGM ANTIBODIES AGAINST MYELIN-ASSOCIATED GLYCOPROTEIN

The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

Efficient synthesis of two HNK-1 related pentasaccharides

Two pentasaccharides, representative of those found on complex N-glycans, were synthesized for use as potential substrates for sulfotransferases. The synthesis was achieved by the addition of a disaccharide donor β-D-GlcA(1→3)α-D-Gal-trichloroacetimidate