635706-26-2Relevant academic research and scientific papers
Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors
Ellis, Christopher D.,Oppong, Kofi A.,Laufersweiler, Michael C.,O'Neil, Steven V.,Soper, David L.,Wang, Yili,Wos, John A.,Fancher, Amy N.,Lu, Wei,Suchanek, Maureen K.,Wang, Richard L.,De, Biswanath,Demuth Jr., Thomas P.
, p. 4728 - 4732 (2007/10/03)
A series of monocyclic thiazepine inhibitors of interleukin-1β converting enzyme (ICE) were synthesized in eight steps from commercially available intermediates. In vitro biological evaluation showed the thiazepines to be moderately potent ICE inhibitors,
DERIVATIVES OF AZEPINE AND THIAZERAN AS INTERLEUKIN CONVERTING ENZYME INHIBITORS
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Page 88, 89, (2010/02/04)
The present invention relates to interleukin - Iβ converting enzyme inhibitors of formula I: wherein each X is independently selected from: i) -C(W)2-; ii) -C(O)-; iii) -NR2-; iv) -S-; v) -S(O)-; vi) -S(O)2-; vii) two units, one from each adjacent X unit,
